Real-Time PCR for the Detection of Vaginal Group B Streptococcus Carriage: a Medico-Economic Study
- Conditions
- Neonatal InfectionsStreptococcus Agalactiae
- Registration Number
- NCT00920530
- Brief Summary
Group B streptococcus infections may be serious for the neonates. The infection can occur during the birth, by contact with the genital area. That is why the detection of this bacteria is systematically realised in pregnant women between 34 and 37 weeks of amenorrhea in order to give prophylactic antibiotic treatment in case or positive carriage. This strategy presents 2 disadvantages : (1) detection of the group B streptococcus at 34 and 37 weeks of amenorrhea in not predictive of a carriage at delivery, (2) many pregnant women escape from systematic screening, leading to a systematic antibiotic treatment, which means useless costs, and useless antibiotic exposure with resistant bacteria selection. Real time polymerase chain reaction (PCR) allows a rapid detection anytime with no specific microbiological qualification. The aim of the study is to assess the economic outcomes of this strategy and the epidemiological values for St Etienne hospital.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 224
- women giving birth
- planned caesarian
- minor
- cervical diameter > 5 cm
- women giving birth at less than 35 weeks of amenorrhea
- recent antibiotherapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method number of women receiving a useless antibiotic prevention 1 day
- Secondary Outcome Measures
Name Time Method diagnosis efficacy of the real time PCR 1 day epidemiological outcomes for group B streptococcus 1 day economic outcomes 1 day
Trial Locations
- Locations (1)
CHU de Saint-Etienne
🇫🇷Saint-etienne, France