The Effect Of Cabergoline On Follicular Microenvironment Profile In Patients With High Risk Of Ohss
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 主要终点
- Concentrations of follicular fluid AMH
研究概览
简要总结
Cabergoline prevents ovarian hyperstimulation syndrome in high risk patients by disrupting follicular fluid hormone microenvironmentally altering the follicular fluid levels of insulin like growth hormone -I (IGF-I), antimullerian hormone (AMH), inhibin B and hepatocyte growth factor (HGF) levels in women with PCOS and high risk of ovarian hyperstimulation syndrome (OHSS).
详细描述
Dopamine agonists have been proposed as a prophylactic treatment for OHSS in women with high risk of OHSS, however the possible mechanism of action has not been clearly known. In experimental studies, inhibition of vascular endothelial growth factor based pathway was proposed as a possible action of mechanism of dopamine agonists. However the role hepatocyte growth factor (HGF), insulin like growth factor-I (IGF-I), inhibin B and antimullerian hormone (AMH) on cabergoline action in OHSS prevention has not been known.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 23 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Development of more than 14 leading follicles larger than 10 mm and serum estradiol more than 3000 pg/ml at the end of ovulation induction with long luteal ovulation induction protocol.
- •Having the criteria of PCOS
排除标准
- •Not having the inclusion criteria.
研究组 & 干预措施
Cabergoline administered group
The patients in this group will have cabergoline (Dostinex tablet, Pfizer, Istanbul, Turkey, started on day of HCG, 0.5 mg/day for 8 days) for prevention of OHSS.
All patients were administered long luteal protocol for ovulation induction.
干预措施: Cabergoline (Drug)
结局指标
主要结局
Concentrations of follicular fluid AMH
时间窗: 1 year
次要结局
- Concentrations of follicular fluid inhibin B(1 year)
- Concentrations of follicular fluid HGF(1 year)
研究者
Assoc. Prof. Emine Seda Guvendag Guven
Assoc. Prof.
Etlik Zubeyde Hanim Womens' Health and Teaching Hospital