Intravitreal Bevacizumab Therapy for Neovascular Age-Related Macular Degeneration: A Pilot Study
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Age Related Macular Degeneration
- Sponsor
- Asociación para Evitar la Ceguera en México
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Improvement of visual acuity at 6 months
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study is to determine whether intravitreal injection of bevacizumab is effective in the treatment of neovascular age related macular degeneration
Detailed Description
The neovascular age related macular degeneration(AMD) is a important cause of legal blindness in adults older than 50 years. Currently the treatment is photodynamic therapy that offer stabilization and limited visual improvement after 2 years of therapy. Bevacizumab has been reported effective used as intravenous injection for AMD. But serious side effects have been reported with the use of this drug in oncologic patients. The intravitreal use has been reported in limited case reports and safety and efficacy should be determined. The purpose of this study is efficacy and safety of 2.5 mg intravitreal of bevacizumab for AMD
Investigators
Eligibility Criteria
Inclusion Criteria
- •age \>50 age related macular degeneration
Exclusion Criteria
- •moderate to severe cataract glaucoma intraocular surgery diabetes mellitus non controlled hypertension coronary artery disease
Outcomes
Primary Outcomes
Improvement of visual acuity at 6 months
Secondary Outcomes
- Leakiness in fluorangiography at 6 months
- Retinal thickness at 6 months