Comparative Evaluation of different doses of Dexmedetomidine for the treatment of shivering in parturients undergoing Caesarean section under Subarachnoid block
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 123
- 试验地点
- 1
- 主要终点
- Shivering scores in groups with different dexmedetomidine doses
研究概览
简要总结
After caesarean delivery shivering can cause maternal discomfort and can interfere with oxygen saturation electrocardiogram and blood pressure monitoring. Therefore, developing strategies for treating shivering may improve the care that we provide to our parturient. Dexmedetomidine, a highly selective alpha 2 adrenoreceptor agonist, is considered a valuable medication in the current obstetric anaesthesia. Here we are trying to compare the efficacy of three different doses of Dexmedetomidine for the treatment of shivering in patients undergoing caesarean section under spinal anaesthesia. The Methodology and administration of drug shall be explained in detail with a written informed consent from the patient. The parturients will be divided into three groups of 41 each using block randomisation technique ( Group D1 will receive 0.3 mcg/kg of i.v dexmedetomidine on occurrence of shivering, Group D2 will receive 0.35mcg/kg of i.v dexmedetomidine and Group D3 will receive 0.4 mcg/ kg of i.v dexmedetomidine when they present with shivering).Patient will be taken in OT and standard monitoring will be attached and baseline vital parameters will be noted. A subarachnoid block will be performed in lateral decubitus position. On occurrence of shivering patient will be given allocated group drug and will be observed for 45 minutes. Shivering score, hemodynamic parameters, Sedation Score, time taken to reduce shivering score, duration of antishivering effect and dose of rescue antishivering drug if given shall be noted. Side effects related to dexmedetomidine injection will be recorded and treated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 42.00 Year(s)(—)
- 性别
- Female
入选标准
- •ASA Grade 2 gestational age more than equal to 37 weeks scheduled for elective c-section under subarachnoid block who present with shivering.
排除标准
- •Parturients with Height less than 150cm or more than 170 cm Initial body temperature of more than 38 degree Celsius or less than 36 degrees Celsius.
- •Chronic user of adrenergic receptor blockers or calcium channel blockers.
- •Known history of alcohol or substance abuse or post-partum hemorrhage.
结局指标
主要结局
Shivering scores in groups with different dexmedetomidine doses
时间窗: Reduction of Shivering scores within 10 minutes in groups with different dexmedetomidine doses assessed by Crossley Et al shivering score.
次要结局
- 1.Time taken for reduction of shivering score less than one after inj. dexmedetomidine(2.Duration of anti shivering effect.)
研究者
Pooja Arya
Vardhman Mahavir Medical College and Safdarjung Hospital
