(TIMP-2)x(IGFPB7) to Predict Acute Kidney Injury (AKI) in Aortic Surgery

Completed

• Conditions: Aortic Surgery; Acute Kidney Injury; Renal Failure; Dialysis; Biomarker
• Interventions: Other: does not apply

• Registration Number: NCT03469765
• Lead Sponsor: Jörg Schefold

Brief Summary

New biomarkers that predict the development of renal dysfunction in patients with aortic surgery are urgently needed. The investigators investigate whether urinary (TIMP-2)x(IGFBP7) predicts postoperative Acute Kidney Injury and/or need for Renal Replacement Therapy (RRT) in patients after aortic surgery (including EVAR).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-03-09
• Study First Submitted QC: 2018-03-16
• Study First Posted: 2018-03-19
• Study Start: 2018-06-19
• Status Verified: 2019-09
• Primary Completion: 2019-09-23
• Study Completion: 2019-09-23
• Last Update Submitted: 2019-09-23
• Last Update Posted: 2019-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients in need of emergency or elective abdominal aortic surgery (infra- or suprarenal clamping or EVAR) are eligible for study inclusion.

Exclusion Criteria

• Patients unable to give informed consent
• Age < 18
• Patients not speaking German or French.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group of patients after aortic surgery	does not apply	with subanalysis of patients with/without supra-/infrarenal surgery

Primary Outcome Measures

Name	Time	Method
Statistically significant difference in mean total (TIMP-2)x(IGFBP7) values of patients with/ without AKI (as defined along Kidney Disease Initiative for Improvement of global outcomes (KDIGO) definitions: stages 1-3) at the first postoperative day.	24 hours following ICU admission

Trial Locations

Locations (1)

Inselspital; 🇨🇭 Bern, Switzerland