Maternal Serum Progesterone And Placental Heme Oxgenase-1 Expression In Early Onset Idiopathic Fetal Growth Restriction: A Case Control Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- Maternal serum level of progesterone
研究概览
简要总结
The study aims to investigate the responsible factors that leads to idiopathic fetal growth restriction.
详细描述
The study aims to investigate the relationship between maternal serum level of progesterone, immune-expression of HMOX-1 a placental angiogenesis marker with idiopathic fetal growth restriction.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •singleton
- •dated pregnancy
排除标准
- •fetus with structural or chromosomal anomaly
- •receive treatments such as aspirin, progestogen, low molecular weight heparin
- •has pre-existing medical disorders such as autoimmune disease, hypertension, diabetes
- •suspected intrauterine infection
研究组 & 干预措施
Women with pregnancies affected by idiopathic fetal growth restriction
Women with normal pregnancies and normally growing foetus
结局指标
主要结局
Maternal serum level of progesterone
时间窗: At the point of recruitment from 24 until 32 weeks gestation.
Maternal blood will be withdrawn and serum isolated. Measurement of progesterone level will be performed from the serum sample using ELISA.
Placental immunoexpression of Heme Oxygenase 1
时间窗: At delivery within 24 until 38 weeks gestation.
Immunoexpression of Heme Oxygenase 1 in syncytiotrophoblasts, cytotrophoblasts, fetal endothelial cells, maternal vessels and decidual cells.
次要结局
- Placenta histopathology examination(At delivery within 24 until 38 weeks gestation)