ADIE to prevent development of anxiety disorders in autism

Not Applicable

Completed

• Conditions: Specialty: Mental Health, Primary sub-specialty: Developmental disorders - Autism; UKCRC code/ Disease: Mental Health/ Disorders of psychological development; Mental and Behavioural Disorders; Anxiety disorders in high-functioning autism

• Registration Number: ISRCTN14848787
• Lead Sponsor: Sussex Partnership NHS Foundation Trust

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34401684/ (added 18/08/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-25
• Study Completion: 2021-03-31
• Last Update Posted: 29 August 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

1. ADI-R confirmed ASC diagnosis
2. Aged 18 and over
3. Normal or corrected-to-normal vision
4. Fluent English speakers

Exclusion Criteria

1. Age below 18 years
2. Past head injury or neurological disorders
3. History of major medical or psychiatric disorder (other than anxiety and co-morbid depression)
4. Cognitive impairment
5. History of substance or alcohol dependence
6. Heart disease
7. Obesity (body mass index > 30kg/m2)
8. Hypertension (>140/90 mm Hg)
9. Pregnancy
10. Asthma/respiratory illness
11. Migraines
12. Claustrophobia or other MRI exclusions
13. Upper age limit of 65

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Current primary outcome measure as of 11/01/2021:<br><br> Spielberger STAI trait anxiety at 3 months<br><br> _____<br><br> Previous primary outcome measure:<br><br> Trait and state anxiety is measured using the STAI trait anxiety score State-Trait Anxiety Inventory determined from the STAI (State-Trait Anxiety Inventory questionnaire) at 3 months.<br>