NL-OMON37478已完成不适用
Pharmacokinetics of intravenous acetaminophen and its metabolites in morbidly obese patients - APAP study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Inclusion criteria for morbidly obese patients:
- •- BMI > 40 kg/m2 undergoing bariatric surgery.
- •- 18 -60 years old
- •- ASA physical classification of II or III
- •- All racial and ethnic groups will be included;Inclusion criteria for normal weight patients:
- •- BMI between 18 and 25 kg/m2 undergoing general surgery
- •- 18 -60 years old
- •- ASA physical classification of I, II or III
- •- All racial and ethnic groups will be included
排除标准
- •Exclusion criteria for all patient groups:
- •- Renal insufficiency identified by GFR < 60 ml/min/1.73m2
- •- Liver disease identified by liver function tests: ASAT, ALAT, prothrombin time, *-GT, bilirubin, creatinine, albumin and alkaline phosphatase (ALP) ( > 3 times upper limit of normal values)
- •- Patients with Gilbert-Meulengracht syndrome
- •- Chronic alcohol intake or use of alcohol within last 72 hours
- •- Pregnancy or breastfeeding
- •- Patients who are treated with drugs know to affect CYP2E1 (inhibition: dithiocarb and disulfiram. Induction: isoniazid) and UGT (UDP-glucuronyltransferases) (induction: estradiol-containing contraceptives, carbamazepine, phenobarbital, phenytoin, mesuximide, oxcarbazepine, rifampicin, primidone, atazanavir / ritonavir, lopinavir / ritonavir, olanzapine, retigabine , nevaripine, efavirenz, saquinavir, nelfinavir, lamotrigine, felbamate, zonisamide, bupropion. Inhibition: valproic acid)
- •- Diabetes mellitus type II patients
- •- Acetaminophen intake before the study (24 hours before study)
研究者
相似试验
进行中（未招募）
不适用
Elimination of acetaminophen in patients with extreme overweightMorbid obesityEUCTR2012-000956-32-NLSt. Antonius Ziekenhuis
已完成
不适用
Comparative pharmacokinetic study of acetaminophen between Japanese and Chinese(Han-people)healthy male subjectsJPRN-UMIN000003637Clinical trial Center,Kitasato University East Hospital16
已完成
3 期
The comparison between intravenous acetaminophen versus oral ibuprofen in preterm newborns with patent ductus arteriosusPatent ductus arteriosusIRCT20190206042639N1Tehran University of Medical Sciences80
已完成
3 期
Effects of acetaminophen on post tonsillectomy paiHypertrophy of tonsils.Chronic diseases of tonsils and adenoidsIRCT201208138075N3Vice chancellor for research, Tehran University of Medical Sciences84
已完成
不适用
Analgesic effect of intravenous acetaminophen and flurbiprofen after elective breast surgerybreast cancerJPRN-UMIN000015334Department of anesthesiology, Kumamoto university40