Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,904
- 试验地点
- 7
- 主要终点
- Diagnosis of heart failure within 6 months
研究概览
简要总结
This is an international prospective, multicentre, unblinded, randomised-controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients.
详细描述
The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure (HF) in high-risk patients.
Participants will be recruited from 5-countries (Denmark, Canada, United States of America, Sweden and Scotland). Individual patient data from similar national randomised controlled trials that are independently powered for different efficacy endpoints will be pooled, harmonised and analysed.
After agreeing to consent, patients will be randomised to one of two arms:
"Routine care arm" - patients in this arm will undergo routine care. They will be managed and followed up as per routine clinical care. They will be remotely monitored for HF events by follow up through electronic records and routinely collected data.
OR
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female ≥40 years of age
- •Informed consent
- •Two or more of the following risk factors for heart failure:
- •Coronary artery disease (either a previous documented type 1 myocardial infarction or coronary artery bypass grafting or percutaneous coronary intervention or documented stenosis of an epicardial coronary artery [50% left main stem or >70% left anterior descending, circumflex or right coronary artery])
- •An established diagnosis of diabetes (type 1 or type 2)
- •Persistent or permanent atrial fibrillation (not paroxysmal atrial fibrillation)
- •Previous ischemic or embolic stroke
- •Peripheral arterial disease (previous surgical or percutaneous revascularisation or a documented stenosis greater than 50% of a major peripheral arterial vessel).
- •Chronic kidney disease (defined as an estimated glomerular filtration rate <60mL/min/1.73m2 or eGFR 60-90mL/min/1.73m2 and UACR >300mg/g).
- •Regular loop diuretic use (any dose at any dosing interval) for >30 days.
- •COPD (evidenced by one of the following: PFTs showing airway obstruction, diagnosis by respiratory physician, CT scan reporting presence of emphysema or treatment with national guideline advocated COPD therapy).
排除标准
- •Inability to give informed consent e.g., due to significant cognitive impairment
- •Previous documented diagnosis of heart failure
- •Current renal replacement therapy
- •Anyone who, in the investigators' opinion, is not suitable to participate in the trial for other reasons e.g., a diagnosis which may compromise survival over the study period
研究组 & 干预措施
Routine care arm
Patients in this arm will undergo routine care. They will be managed and followed up as per routine clinical care. They will be remotely monitored for HF events by follow up through electronic records and routinely collected data.
Investigational arm
Patients in this arm will have a blood sample performed for measurement of N-terminal prohormone of B-type natriuretic peptide (NT-proBNP). Patients with an elevated Roche NT-proBNP (≥125 pg/mL) will undergo a transthoracic echocardiogram, clinical examination for signs of HF, HF symptom assessment, an ECG). Patients will undergo echocardiography with a CE-marked, FDA-approved handheld point of care (POC) EchoNous echocardiogram device in all countries. The US2.ai algorithm (which is also CE-marked and FDA-approved) will generate an AI-automated echocardiogram report.
干预措施: NT-proBNP (Diagnostic Test)
结局指标
主要结局
Diagnosis of heart failure within 6 months
时间窗: 6 months
次要结局
- Diagnosis of HFrEF within 6 months(6 months)
- People diagnosed with HFrEF receiving GDMT within 6 months(6 months)