A Prospective Study of Validation of the fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Women With Pre- Eclampsia in Sohag University Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Validation of the fullPIERS prediction model for adverse maternal outcomes using logistic regression-derived predicted probabilities
研究概览
简要总结
Apredictive formula, fullPIERS (Pre-eclampsia Integrated Estimate of Risk Score), can be used to estimate the risk of suffering an adverse outcome using information obtained within 48 hours of admission with pre-eclampsia. The following information is used, serum creatinine, gestational age, platelet count,
详细描述
Inclusion criteria Patients diagnosed with preeclampsia, defined by hypertension (systolic BP
≥140 mmHg and/or diastolic BP ≥90 mmHg, measured twice more than 4 hours apart after 20 weeks gestation) Proteinuria of at least 0.3 g/dl or ≥300 mg of protein in a 24-hour urine collection Urine albumin-creatinine ratio (ACR) ≥30 mg/mmol, or hypertension with end organ dysfunction after20 weeks gestation
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Inclusion Criteria Female patients diagnosed with preeclampsia. Gestational age ≥ 20 weeks.
- •Hypertension defined as:
- •Systolic blood pressure ≥ 140 mmHg and/or Diastolic blood pressure ≥ 90 mmHg, measured on at least two occasions more than 4 hours apart.
- •Proteinuria defined as:
- •300 mg protein in a 24-hour urine collection or
- •0.3 g/dL on urine analysis. Singleton pregnancy.
排除标准
- •Patients who do not meet the clinical or laboratory diagnostic criteria of preeclampsia.
结局指标
主要结局
Validation of the fullPIERS prediction model for adverse maternal outcomes using logistic regression-derived predicted probabilities
时间窗: 1year
Evaluate the validity of the fullPIERS model in the prediction of adverse maternal outcomes in women with pre-eclampsia in Sohag Governorate, Egypt.
时间窗: 1year
The collected data are then will be used to calculate the predicted probability of adverse outcomes using the fullPIERS logistic regression equation logit(p)=2.68+(-5.41×10-2×gestational age) +1.23×(chest pain or dyspnea)+(-2.71×10 -2×creatinine) .
次要结局
未报告次要终点
研究者
Alaa Abdellah Mohmed
Residant
Sohag University