Immunoglobulin G Antibody Immune Response Profile Following Infection With SARS-CoV-2 in COVID-19 Egyptian Patients

Completed

• Conditions: Covid19

• Registration Number: NCT04483622
• Lead Sponsor: Sohag University

Brief Summary

The objective of this study is to detect the evidence on the immune response following acute SARS-CoV-2 infections. the study will report the profile of IgG specific antibodies levels to SARS-CoV-2 infection found in recovered coronavirus disease (COVID-19) patients after infection for both symptomatic and asymptomatic patients.

Detailed Description

A total of 30 COVID-19 patients for the study will be enrolled. All the patients enrolled were confirmed to be infected with SARS-CoV-2 by RT-PCR assay for nasal and pharyngeal swab specimens.

For the study, serum samples of the 30 patients will be collected and will be investigated for the detection rate for immunoglobulin G (IgG). The first sample will be collected 2 weeks after the second negative RT-PCR assay for nasal and pharyngeal swab specimens and 6 samples will be collected after that for 6 months later; one serum sample tested every month for 6 months after.

The following questions will be addressed:-

1. What proportion of confirmed cases develops specific IgG antibodies to SARS-CoV-2?

2. How long is the duration of detection of serum IgG antibodies and antibody titres over time following infection with SARS-CoV-2?

Study Timeline

• Study Start: 2020-07-12
• Study First Submitted: 2020-07-21
• Study First Submitted QC: 2020-07-21
• Study First Posted: 2020-07-23
• Primary Completion: 2021-12-15
• Study Completion: 2021-12-25
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-10
• Last Update Posted: 2022-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• patients with recent COVID- 19 infection(2 weeks after the second negative RT-PCR assay)

Exclusion Criteria

• patients on immune-suppressive therapy
• patients with immunological disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
rising titre of IGg antibodies	first month	it's expected to have COVID-19 antibodies within 1month of infection the antibody titre expected to rise the fall to a lower levels

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt