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Clinical Trials/NCT04455425
NCT04455425CompletedNot Applicable

Descriptive Cohort of Acquired Syphlis by Non Sexual Contact

Hospital de Niños R. Gutierrez de Buenos Aires1 site in 1 country24 target enrollmentStarted: July 15, 2020Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
24
Locations
1
Primary Endpoint
Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts

Study Overview

Brief Summary

Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always considered and must be ruled out by specialists in a careful evaluation.

However, muco-cutaneous lesions can be a contagious source for congenital syphilis; therefore the possibility of non-sexual transmission through intimate contact with infected people through humid lesions (such as in kisses, breastfeeding, food-handling) or contaminated fomites (towels, bed sheets, underwear, cups, pacifiers, cutlery) could be considered. Experts worldwide have observed this non-sexual transmission, as described in many reports in literature.

The investigators will study retrospectively patients from a cohort with non-sexual transmission. The diagnosis criteria used for acquired syphilis were as follows: age under 18 years with treponemic and nontreponemic positive tests, secondary-syphilis suspicious lesions and negative maternal syphilis serology. Nonsexual contagious was defined as contacts without physical and psychosocial indicators of sexual abuse according to current guides. In this cohort, in every case a psychosocial evaluation was completed with a written report in order to evaluate sexual contact probability.

The teamo will describe these patients clinical and laboratory findings, family and close acquaintances serologies and probable source of contagious.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Retrospective

Eligibility Criteria

Ages
0 Years to 18 Years (Child, Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts

Time Frame: Past 20 years

Investigators will report serology titers from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening

Describe reported symptoms and physical findings at diagnose and during follow-up f children with assumed non-sexual acquired syphilis and their close contacts

Time Frame: Past 20 years

Investigators will describe symptoms and physical findings from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening

Describe diagnose process of a cohort of children with assumed non-sexual acquired syphilis

Time Frame: Past 20 years

Describe the interdisciplinary approach of patients with acquired syphilis and how non-sexual transmission was assumed

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Hospital de Niños R. Gutierrez de Buenos Aires
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Dr Jaime Altcheh

Principal Investigator

Hospital de Niños R. Gutierrez de Buenos Aires

Study Sites (1)

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