STUDY OF CORRELATION BETWEEN MARKERS OF COAGULATION AND CLINICAL SEVERITY IN COVID 19

Recruiting

Conditions: Coronavirus as the cause of diseases classified elsewhere,

Registration Number: CTRI/2020/12/029984

Lead Sponsor: Smt NHL Municipal Medical College

Brief Summary: **Study Design:**

Cross sectional, prospective, observational study

**Study Duration:**

24 months after IRB/CTRI approval

**Hypothesis:**

- In patients with COVID-19, there is a progression from adaptive hemostasis to pathologically induced Disseminated Intravascular Coagulopathy (DIC) to multi organ failure.

- Hence, coagulation profile in Covid 19 disease could be a significant marker to predict the clinical severity of disease and hence the overall outcome of patients from the disease.

**Aims and Objectives:**

- Studying the coagulation markers and their progression in COVID-19 .

- Correlation of coagulation markers with the clinical severity of COVID-19

- Outcome of patients with elevated coagulation markers in terms of:

- In-hospital stay (Duration and Type of stay: ICU or Ward)

- Morbidity (PE, DVT,Stroke,etc)

- Mortality

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 100

Inclusion Criteria

Inpatients in General Medicine with a established diagnosis of COVID 19 infection( Laboratory confirmed ) Patients with abnormal coagulation markers Patients of age >18 years.

Exclusion Criteria

Patients with proven others causes of coagulopathy.
VTE, DVT, Recent Surgery/Trauma, Pregnancy, Cancer Patients already on anticoagulant therapy.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In-hospital stay (Duration and Type of stay: ICU or Ward)	At Baseline, Every 3rd Day till Discharge/Death

Secondary Outcome Measures

Name	Time	Method
Morbidity (PE, DVT,Stroke,etc)	Mortality

Trial Locations

Locations (1): Sardar Vallabhbhai Patel Institute of Medical Science and Research (SVPIMSR)
🇮🇳
Ahmadabad, GUJARAT, India
Sardar Vallabhbhai Patel Institute of Medical Science and Research (SVPIMSR)
🇮🇳Ahmadabad, GUJARAT, India
DR AKASH J JANI
Principal investigator
8460706921
akash.jani@gmail.com