Gender, Obesity, C-Reactive Protein, and Oxidative Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 396
- 试验地点
- 2
- 主要终点
- Change in high-sensitivity C-reactive protein (hsCRP)
研究概览
简要总结
This randomized placebo-controlled trial will test whether supplementing with vitamins C and E can lower markers of inflammation and oxidative stress in healthy adults. We will examine whether one antioxidant vitamin is more effective than another, and whether gender or body fat influence the treatment effects. We will also determine whether gender, body fat, or menopausal status are associated with baseline concentrations of inflammation and oxidative stress markers.
详细描述
Participants will be given 1000 mg vitamin C or 800 IU vitamin E daily for 60 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Z
Placebo
干预措施: Placebo (Dietary Supplement)
Y
Vitamin E
干预措施: Vitamin E (Dietary Supplement)
X
Vitamin C
干预措施: Vitamin C (Dietary Supplement)
结局指标
主要结局
Change in high-sensitivity C-reactive protein (hsCRP)
时间窗: 8-week intervention
次要结局
- Change in blood pressure(8-week intervention)
- Change in self-reported stress and psychosocial factors(8-week intervention)
- Change in oxidative stress biomarkers (F2-Isoprostanes, malondialdehyde)(8-week intervention)
- Association of gender, body fat, menopausal status with baseline concentrations of inflammation and oxidative stress biomarkers.(Baseline)