Neurophysiological Study of tDCS Effects in Healthy Volunteers

Phase 1

Completed

• Conditions: Healthy Volunteers
• Interventions: Device: Cefaly tDCS

• Registration Number: NCT02125422
• Lead Sponsor: University of Liege

Brief Summary

Transcranial direct current stimulation is a tool to modulate cortical excitability.

Detailed Description

Anodal transcranial direct currenti stimulation over visual cortex is able to decrease the thermo-nociceptive sensibility and thermonociceptive potentials, whilst cathodal transcranial direct current stimulation has the opposite effect, it decreases VEP amplitude and habituation. This neuromodulation technique is probably a tool in the prevention in episodic and chronic migraine.

The aim of the study is to study short and long term effect of tDCS over pain treshold, contact heat evoked potentials, blink reflex and visual evoked potentials in healthy volunteers.

Study Timeline

• Study Start: 2013-11
• Primary Completion: 2013-12
• Study Completion: 2014-04
• Study First Submitted: 2014-04-18
• Study First Submitted QC: 2014-04-25
• Study First Posted: 2014-04-29
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-27
• Last Update Posted: 2015-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• healthy volunteers

Exclusion Criteria

• age below 18 or above 65 years
• personal history of recurrent headache or other neurological diseases especially seizures,
• familial history of recurrent headache
• child migraine equivalents (motion sickness, cyclic vomiting or recurrent abdominal pain, somnambulism etc.. . .)
• chronic pain syndromes
• analgesics intake at the time of recording
• contra-indications to tDCS neurostimulation (metal prosthetics in the head or internal stimulation like a pacemaker).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cefaly tDCS	Cefaly tDCS	Cathodal Cefaly tDCS is delivered over the visual cortex at 2 mA of intensity, for 20 minutes, for 5 consecutive days in 9 HV. The anode is placed over the left DLPFC. 2 mA anodal tDCS is delivered over the visual cortex, for 20 minutes, for 5 consecutive days in 9 HV

Primary Outcome Measures

Name	Time	Method
Neurophysiological mesures changes	up to 1 month	Modifications in neurophysiological test after direct current stimulation

Trial Locations

Locations (1)

Roberta Baschi; 🇧🇪 Liége, Belgium