Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections
- Conditions
- Thoracic DiseasesCancer of the Digestive System
- Interventions
- Other: Collection of plasma cell rate
- Registration Number
- NCT02799251
- Brief Summary
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis. The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery.
- Detailed Description
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis.
The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery. It is a multicenter French cohort study. Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery before surgery (day-0) as well 1, 3, 5 and 8 days after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1125
- patient undergoing digestive or thoracic cancer surgery under general anesthesia.
- pregnant women,
- malignant blood disease,
- allograft patient,
- preoperative sepsis or preoperative systemic inflammatory response syndrome.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Collection of plasma cell rate Collection of plasma cell rate Post operative infections and their association with lymphopenia are assessed in this study for patients over 18 years of age undergoing digestive or thoracic cancer surgery under general anesthesia.
- Primary Outcome Measures
Name Time Method Presence of post operative infection 1 month Patients undergoing general anesthesia for thoracic or digestive surgery could present lymphopenia. In this situation, the presence of post operative infection is notified. The correlation between lymphopenia and post operative infections is studied.
- Secondary Outcome Measures
Name Time Method Anesthetic and surgical parameters 1 month To identify anesthetic and surgical parameters influencing postoperative lymphocytes cells count.
Trial Locations
- Locations (20)
H么pital C么tes de Nacre CHU CAEN
馃嚝馃嚪Caen, France
H么pital Edouard Herriot CHU LYON
馃嚝馃嚪Lyon, France
H么pital La croix Rousse CHU LYON
馃嚝馃嚪Lyon, France
H么pital Beaujon CHU PARIS 1
馃嚝馃嚪Clichy, France
Chu Angers
馃嚝馃嚪Angers, France
H么pital Estaing CHU CLERMONT-FERRAND
馃嚝馃嚪Clermont-Ferrand, France
H么pital Michallon CHU GRENOBLE
馃嚝馃嚪La Tronche, France
H么pital Huriez CHRU LILLE
馃嚝馃嚪Lille, France
H么pital Lyon Sud CHU LYON
馃嚝馃嚪Lyon, France
H么pital Nord CHU MARSEILLE
馃嚝馃嚪Marseille, France
H么pital La Timone CHU MARSEILLE
馃嚝馃嚪Marseille, France
H么pital Saint-Antoine CHU PARIS 4
馃嚝馃嚪Paris, France
H么pital Car茅meau CHU NIMES
馃嚝馃嚪N卯mes, France
H么pital H么tel-Dieu CHU NANTES
馃嚝馃嚪Nantes, France
H么pital Saint Louis-Lariboisi猫re CHU PARIS 5
馃嚝馃嚪Paris, France
H么pital La piti茅-Salpetri猫re CHU PARIS 3
馃嚝馃嚪Paris, France
H么pital Bichat CHU PARIS 2
馃嚝馃嚪Paris, France
H么pital Pontchaillou CHU RENNES
馃嚝馃嚪Rennes, France
H么pital Central CHRU STRASBOURG
馃嚝馃嚪Strasbourg, France
Centre de Lutte contre le Cancer, TOULOUSE
馃嚝馃嚪Toulouse, France