Hip Fracture and COVID-19

Completed

• Conditions: SARS-CoV2 Infection; Hip Fractures; Surgery
• Interventions: Procedure: Hip fracture surgery

• Registration Number: NCT04944329
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

Hip fracture in the elderly is a worldwide public health issue and a medical challenge for early postoperative rehabilitation. More than 2 million people are treated annually with an annual incidence between 100 and 300/100,000 (USA, Europe, China), resulting in a cost of billion dollars and a strain on most surgical facilities. In this context, an early surgical management of patient with fracture within the first 24-48h has been shown to reduce morbidity, length of hospital stay and mortality.

During the Covid-19 pandemics, a higher risk of 30-day mortality has been reported in patients with pre-operative SARS-CoV-2 infection diagnosed 0-2 weeks, 3-4 weeks and 5-6 weeks before surgery compared with patients who did not have a pre-operative SARS-CoV-2 infection. However, this risk seems to disappear in patients diagnosed with SARS-CoV-2 ≥ 7 weeks before surgery. These findings led to propose delayed elective surgery when the benefit-risk ratio was acceptable (cancer, cardiac surgeries). However, delaying surgery in COVID-19 patients (with high risk of immune and thrombotic disorders) with hip fracture could be questionable as the risk related to COVID-19 could be counteracted by the risk delayed surgery.

For assessing the mortality risk related to hip fracture surgery associated with COVID-19, we decided to use the French national hospital discharge records database for comparing the 30-day postoperative mortality in patients with hip fracture and with or without an hospitalization for SARS-COV-2 infection in the 30 previous days before surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-01
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-06
• Study First Submitted: 2021-06-26
• Study First Submitted QC: 2021-06-26
• Study First Posted: 2021-06-29
• Last Update Submitted: 2021-06-29
• Last Update Posted: 2021-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 73661

Inclusion Criteria

• Age > 65 yars
• hip fracture hospitalization
• care code indicating a surgical procedure

Exclusion Criteria

-Patient with hip fracture hospitalization without a care code indicating a surgical procedure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COLCOVID	Hip fracture surgery	adults undergoing hip fracture surgery

Primary Outcome Measures

Name	Time	Method
Hospital Mortality	Day 0 to Day 30	hospital mortality within 30 days of the date of hospital admission for hip fracture

Trial Locations

Locations (1)

CHU de NIMES; 🇫🇷 Nimes, France