Predictive Utility of Monocyte-to-Albumin Neutrophil to Albumin and Total Leukocytic Count-to-Albumin Ratios in Ischemic Stroke. A Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- Stroke severity at admission
研究概览
简要总结
Acute Ischemic Stroke is a leading cause of mortality and long-term disability worldwide. Increasing evidence suggests that systemic inflammation plays a significant role in the pathophysiology and progression of ischemic brain injury. Recently, several inflammatory biomarkers derived from routine laboratory tests have been investigated as potential predictors of stroke severity and clinical outcome.
This prospective cohort study aims to evaluate the predictive utility of the monocyte-to-albumin ratio, neutrophil-to-albumin ratio, and total leukocytic count-to-albumin ratio in patients with acute ischemic stroke. These indices combine inflammatory cell counts with serum albumin levels and may reflect both systemic inflammatory status and nutritional condition.
Stroke severity will be assessed at admission using the NIH Stroke Scale, while functional outcome will be evaluated during follow-up using the Modified Rankin Scale. The study aims to determine whether these simple and readily available biomarkers can serve as reliable predictors of stroke severity and prognosis in patients with acute ischemic stroke.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥ 18 years old) admitted with a diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI).
- •Admission within a defined time window from stroke onset (e.g., within 48 hours) to capture acute inflammatory response.
- •Availability of complete blood count (CBC) with differential and serum -albumin levels at admission.
- •Informed consent obtained from the patient or their legal representative.
排除标准
- •Patients with hemorrhagic stroke or transient ischemic attack (TIA).
- •Patients with previous history of ischemic stroke.
- •Patients who accepted intravenous thrombolysis (IV tPA) and or mechanical thrombectomy.
- •Pre-existing inflammatory or autoimmune diseases (e.g., rheumatoid arthritis, lupus, inflammatory bowel disease) that could influence monocyte count or albumin levels.
- •Active infections (bacterial, viral, fungal) at admission.
- •Severe liver or kidney disease affecting albumin synthesis or catabolism.
- •Hematological disorders affecting white blood cell counts. ⚫ Patients on immunosuppressive therapy or corticosteroids.
- •Patients with known malignancy
- •Lack of complete blood count (CBC) with differential and serum albumin levels at admission.
- •Patients who received blood transfusions before blood sampling.
- •Patients with other acute severe medical conditions that significantly impact inflammatory markers (e.g., sepsis, major trauma).
结局指标
主要结局
Stroke severity at admission
时间窗: At admission
Stroke severity will be assessed using the National Institutes of Health Stroke Scale (NIHSS) at hospital admission. The total score ranges from 0 to 42, with higher scores indicating more severe neurological deficit.
次要结局
未报告次要终点
研究者
Mohamed Mounir Abbas
MSc Candidate, Department of Neurology and PsychologicalMedicine, Faculty of Medicine Sohag University
Sohag University