TCTR20210729003已完成2 期
A randomized, double-blind, split-face study of topical silymarin versus 2% hydroquinone cream in melasma
/A0 个研究点目标入组 23 人开始时间: 2021年7月29日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 23
研究概览
简要总结
After treatment, both sides showed significant improvement of RLI. Mean improvement rates of RLI were 14.56% (SD 43.09) and 12.82 % (SD 38.19) for silymarin and hydroquinone respectively. Modified MASI score decreased after both treatments but was only significant on the hydroquinone side after the first month of treatment (% reduction of modified MASI 17.98%, P 0.019). However, there were no statistically significant differences in the RL*I and modified MASI between the two treatments.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- N/A (No limit) 至 N/A (No limit)（—）
- 性别
- Female
入选标准
- •25 female patients with epidermal or mixed-type melasma on both cheeks
排除标准
- •1.Patients with pregnancy and lactation
- •2. Received hormonal therapy or contraceptive pills within 1 year
- •3. Received any topical treatment within 1 month
- •4. Received laser treatment within 3 months
- •5. Having other facial dermatologic conditions or present of any life-threatening underlying diseases
研究者
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