The effect of probiotic strains on intestinal permeability in well-trained adults
- Conditions
- Gastrointestinal functionDigestive System
- Registration Number
- ISRCTN16686476
- Lead Sponsor
- Chr. Hansen A/S (Denmark)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 48
1. Healthy men or women
2. Age 18 to 40 inclusive
3. Presence of upper or lower gastrointestinal symptoms that interfere with training and during competition
4. Weekly training load of 4 or more hours within endurance sports (minimum 50% of the training should be running activity)
1. History of hypersensitivity to any of the ingredients of the study products or lactose intolerance
2. History or diagnosis of gastrointestinal disease or complicated gastrointestinal surgery
3. Any physical or psychological abnormality or medical condition that could have an effect on gastrointestinal discomfort
4. Participation in any other clinical study
5. Not willing or able to provide written informed consent for participation in the study
6. For women: Not willing and able to use a reliable contraceptive method, pregnancy, lactation or wish to become pregnant
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intestinal permeability after a standardized exercise challenge measured by the in vivo lactulose/rhamnose sugar test at baseline and end of intervention (after 6 weeks)
- Secondary Outcome Measures
Name Time Method Multiple potential biomarkers measured in blood, feces and saliva at baseline and end of intervention (after 6 weeks)