Evaluation of Nail Fold Microcirculation and Interventional Therapy in Patients With Chronic Renal Failure
试验速览
- 阶段
- 4 期
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Nailfold microcirculation morphological integral
研究概览
简要总结
To evaluation of nailfold microcirculation in patients with chronic renal failure and its intervention therapy
详细描述
The aim of this study is to study the changes of Nailfold Microcirculation in patients with chronic renal failure, to clarify the correlation between the changes of Nailfold Microcirculation and renal function, and to explore whether nailfold microcirculation can be used as an indicator of renal microcirculation in patients with chronic renal failure, and to provide a noninvasive method for the clinical evaluation of renal microcirculation in patients with chronic renal failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •CKD patients
- •Without dialysis
- •Blood pressure ≤ 140/90mmHg
排除标准
- •Polycystic kidney
- •Endocrine system disease
- •Cardio-cerebrovascular disease
- •Rheumatic immune disease
- •Peripheral vascular disease
- •Hematological diseases
- •Respiratory disease
- •Infection
研究组 & 干预措施
Experimental group
Alprostadil and Beraprost sodium tablets are used to improve the microcirculation of CKD patients.
干预措施: Alprostadil Injection (Drug)
Experimental group
Alprostadil and Beraprost sodium tablets are used to improve the microcirculation of CKD patients.
干预措施: Beraprost sodium tablets (Drug)
结局指标
主要结局
Nailfold microcirculation morphological integral
时间窗: Up to three and a half months
Nail fold capillary microscopy examination
Nailfold microcirculation blood flow integral
时间窗: Up to three and a half months
Nail fold capillary microscopy examination
Nail fold microcirculation perivascular loop integral
时间窗: Up to three and a half months
Nail fold capillary microscopy examination
次要结局
- The content of blood urea nitrogen(Up to three and a half months)
- The content of blood cystatin C(Up to three and a half months)
- eGFR(Up to three and a half months)
- The content of blood serum creatinine(Up to three and a half months)
- The content of blood albumin(Up to three and a half months)
- The quantification of urinary protein(Up to three and a half months)
- The content of hemoglobin(Up to three and a half months)