An Observational Cohort Study of Associations Between Early Neurological Complications（including Stroke）and Carotid-Cerebral Vascular Disease Among Patients After Coronary Artery Bypass Grafting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,002
- 试验地点
- 1
- 主要终点
- the incidence of 7-day neurological complications
研究概览
简要总结
Review the data of patients who underwent coronary artery bypass grafting (CABG) at the Department of Cardiovascular Surgery in Ruijin hospital from March 2020 to May 2022, including medical history, head and neck CTA, head CT scan, and early postoperative (within 7 days after surgery) neurological complications (defined as a composite of stroke, delayed awakening and severe delirium) . Case-control and retrospective cohorts were built to explore risk factors of early postoperative neurological complications, And its association with baseline carotid-cerebral vascular disease.
Describe the epidemiological data of early postoperative neurological complications (stroke, delayed awakening, and severe delirium) after CABG surgery (within 7 days after surgery); explore independent risk factors of compound neurological complications, build predictive models; compare the effects of carotid-cerebral artery disease on early postoperative compound neurological complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who received CABG at the department of cardiac surgery in our hospital.
- •Surgery that patients received includes both isolated and combined CABG surgery.
- •Includes both cardiopulmonary and non-cardiopulmonary bypass.
排除标准
- •Without complete preoperative examination data, such as carotid-cerebral artery CTA, head CT imaging results and so on.
- •Without complete baseline medical history and 7 day post-surgery record.
结局指标
主要结局
the incidence of 7-day neurological complications
时间窗: within 7 days post-CABG
a composite of stroke, delayed awakening, severe delirium
the incidence of 7-day stroke
时间窗: within 7 days post-CABG
including cerebral infarction, cerebral hemorrhage, and hypoxic-ischemic encephalopathy
the incidence of delayed awakening
时间窗: within 48 hours post-CABG
post-surgery patient does not wake up at 48 hours after withdrawing sedative
the incidence of severe delirium
时间窗: within 7 days post-CABG
ICU CAM-II score≥2 points
次要结局
- the incidence of All-cause death(7 days, 30 days and 1 year post-CABG)
- the incidence of CV-death(7 days, 30 days and 1 year post-CABG)
- the incidence of myocardial infraction(7 days, 30 days and 1 year post-CABG)
- the incidence of repeat revascularization(7 days, 30 days and 1 year post-CABG)
研究者
Qiang Zhao,MD
Professor and Director, Department of Cardiovascular Surgery, Vice President, Ruijin Hospital
Ruijin Hospital