Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy

Not Applicable

Recruiting

• Conditions: Spastic Diplegia
• Interventions: Procedure: 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia

• Registration Number: NCT02535936
• Lead Sponsor: The University of Texas Health Science Center, Houston

Brief Summary

The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.

Detailed Description

To establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (DTI) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcMRI) temporal latency differences of spastic diplegics for Selective Dorsal Rhizotomy.

Study Timeline

• Study Start: 2015-08
• Study First Submitted: 2015-08-25
• Study First Submitted QC: 2015-08-28
• Study First Posted: 2015-08-31
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-05
• Last Update Posted: 2024-12-11
• Primary Completion: 2030-01-01
• Study Completion: 2031-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery

Exclusion Criteria

• No Selective Dorsal Rhizotomy surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
3Tesla MRI with DTI-MRI and rsfcMRI	3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia	Patients will receive 2 post-operative MRI's with DTI and rsfcMRI at 2 months and 12 months.

Primary Outcome Measures

Name	Time	Method
Change in Radial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)
Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR).
Change in Mean Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract Selective Dorsal Rhizotomy (SDR).
Change in Axial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences	Baseline and 12 months	This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)

Trial Locations

Locations (1)

UTHealth & Children's Memorial Hermann Hospital; 🇺🇸 Houston, Texas, United States