Predictive Factors for Exacerbation Outcome in Severe Refractory Asthmatics

Terminated

• Conditions: Chronic Inflammatory Diseases; Asthma

• Registration Number: NCT00721097
• Lead Sponsor: Nantes University Hospital

Brief Summary

Asthma is a chronic inflammatory disease, affecting up to 10 % of the general population in developed countries. Corticosteroids are necessary to control symptoms, but induce adverse events sometimes intolerable. In severe asthma, which represent 5 to 10% of global asthma, corticosteroids frequently fail to prevent severe exacerbations, leading to emergency care, hospitalization and sometimes death. The aim of this study is to identify predictive factors specific for exacerbation outcome which will lead to a minor increase in treatment in order to prevent exacerbations, while minimizing drug adverse effects.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-06
• Study First Submitted: 2008-07-07
• Study First Submitted QC: 2008-07-21
• Study First Posted: 2008-07-23
• Primary Completion: 2011-05
• Study Completion: 2011-05
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-27
• Last Update Posted: 2013-09-30

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of predictive factors for exacerbation outcome in severe asthmatics.

Secondary Outcome Measures

Name	Time	Method
Rate of predictive factors identified in the study, in order to prevent exacerbations.

Trial Locations

Locations (1)

nantes University Hospital; 🇫🇷 Nantes, France