ACTRN12615000615583撤回4 期
A randomised blinded comparison of methadone to morphine in improving postoperative recovery and pain after total abdominal hysterectomy in adult women
适应症
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- Female
入选标准
- •1.ASA I, II or III
- •2.Elective abdominal hysterectomy
- •3.Age < 80
排除标准
- •1.Refusal to participate
- •2.Unable to consent
- •3.Non-English speaking background with inadequate spoken English to complete questionnaire
- •4.Planned pelvic exenteration or radical hysterectomy
- •5.Adverse drug reaction to morphine or methadone, or inability to receive a volatile anaesthetic
- •6.Chronic pain, or taking any regular opioid or chronic pain medication preoperatively (paracetamol, NSAIDs, or tramadol is not an exclusion criteria)
- •7.History of intravenous drug use
- •8.Preoperative renal failure (with eGFR < 60 mL/min), known obstructive sleep apnoea, morbid obesity (BMI > 40 kg/m2), or severe COAD (FEV1 < 50% predicted)
- •9.Use of CYP 2B6 inducers or inhibitors: rifampicin, antiepileptics (carbamazepine, phenobarbital, phenytoin), sertraline, antiplatelets (clopidogrel, prasugrel, ticlopidine), antivirals (efavirenz, nevirapine)
- •10.Use of antipsychotic medication
- •11.Patients with a prolonged QT interval (> 440ms) on preoperative ECG
- •12.Use of selective monoamine oxidase B inhibitors: selegiline, rasagiline
研究者
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