ACTRN12615000615583
Withdrawn
Phase 4
A randomised blinded comparison of methadone to morphine in improving postoperative recovery and pain after total abdominal hysterectomy in adult women
Overview
- Phase
- Phase 4
- Status
- Withdrawn
- Sponsor
- Monash Health
- Enrollment
- 60
Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Treatment
- Masking
- Blinded (masking used)
Eligibility Criteria
- Ages
- 18 Years to 80 Years (—)
- Sex
- Female
Inclusion Criteria
- •1\.ASA I, II or III
- •2\.Elective abdominal hysterectomy
- •3\.Age \< 80
Exclusion Criteria
- •1\.Refusal to participate
- •2\.Unable to consent
- •3\.Non\-English speaking background with inadequate spoken English to complete questionnaire
- •4\.Planned pelvic exenteration or radical hysterectomy
- •5\.Adverse drug reaction to morphine or methadone, or inability to receive a volatile anaesthetic
- •6\.Chronic pain, or taking any regular opioid or chronic pain medication preoperatively (paracetamol, NSAIDs, or tramadol is not an exclusion criteria)
- •7\.History of intravenous drug use
- •8\.Preoperative renal failure (with eGFR \< 60 mL/min), known obstructive sleep apnoea, morbid obesity (BMI \> 40 kg/m2\), or severe COAD (FEV1 \< 50% predicted)
- •9\.Use of CYP 2B6 inducers or inhibitors: rifampicin, antiepileptics (carbamazepine, phenobarbital, phenytoin), sertraline, antiplatelets (clopidogrel, prasugrel, ticlopidine), antivirals (efavirenz, nevirapine)
- •10\.Use of antipsychotic medication
Investigators
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