NCT01242137Unknown不适用
Pharmacogenetic Effect on the Pharmacodynamics of Glibenclamide
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- HbA1c
研究概览
简要总结
Glibenclamide is metabolized by the hepatic enzyme P450 CYP2C9 to less active form. Polymorphism of this enzyme demonstrated clinical significance when examined on other drugs from the sulfonylurea drug family, to whom Glibenclamide is included.
The investigators assumption is that patients with less active alleles of the enzyme may show lower dose requirements of the drug for glycemic control, when compared to patients homozygotes to wild-type alleles.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Tx with metformin and glibenclamide
排除标准
- •Tx which affecting the P450 2C9 action
- •Renal failure
结局指标
主要结局
HbA1c
时间窗: 2 years
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Effect of CYP2C9/CYP2C19 Polymorphism on Pharmacokinetics of Phenobarbital in Korean Neonatal Seizure Patients.Neonatal SeizureNCT01224457Yonsei University52
已完成
4 期
Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar SurgeryPainOther Surgical ProceduresImpacted Third Molar ToothCytochrome P450 CYP2C9 Enzyme DeficiencyNCT02450487University of Sao Paulo105
已完成
1 期
Genetic Determinants of the Metabolism of Non-nucleoside Reverse Transcriptase InhibitorsHIV InfectionsNCT00730223Vanderbilt University33
已完成
2 期
Clopidogrel Pharmacogenomics ProjectDisease SusceptibilityNCT01097343University of North Carolina, Chapel Hill50
招募中
1 期
Risk of CYP2C19 Phenoconversion in Healthy Volunteers With Rapid, Normal, and Intermediate Predicted Metabolizers' StatusHealthyNCT05264142University Hospital, Geneva45