Proposal to investigate the efficacy and tolerability of Aripiprazole as an add-on therapy in patients not responding to an adequate dose of an antidepressant therapy

Manchester Mental Health &Social Care Trust0 个研究点目标入组 90 人开始时间: 2007年1月14日最近更新: 2024年9月9日

适应症

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•-Meets criteria for Major depressive disorder by DSM IV
•-Currently on an adequate dose (within BNF limits) of an antidepressant for at least 6 weeks with and/or other augmentation therapy including lithium and carbamezepine but not antipsychotic medication
•-Have Hamilton Depression rating Scale (HAMD17) total score of >15
•- Agrees to use an effective form of contraception throughout the study
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- DSM IV defined history of substance abuse or dependence within the past year
•-Unstable medical illness (e.g., cardiovascular, liver, kidney, respiratory, endocrine, or neurological disease, including uncontrolled seizure disorder)
•-History of or current psychotic features
•- Patients should not have been on an antipsychotic medication in the past 2 weeks
•-Patients who are receiving psychotherapy

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