NCT03097822Unknown不适用
Response Prediction After Gamma Knife Surgery (GKS) in Patients With Vestibular Schwannoma Using Dynamic Contrast-Enhanced (DCE) MR Imaging
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 主要终点
- Tumor size change before and after surgery
研究概览
简要总结
Response Prediction after Gamma Knife Surgery (GKS) in Patients with Vestibular Schwannoma using Dynamic Contrast-Enhanced (DCE) MR Imaging
详细描述
The purpose of this study was to evaluate the response of Gamma Knife Surgery to Ktrans, Ve, and Vp, which are indicators of permeability map obtained from dynamic contrast enhanced (DCE) MRI in patients with vestibular schwannoma .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with vestibular schwannoma, who underwent gamma knife surgery and pre-op dynamic contrast enhanced (DCE) MRI
- •Patients with vestibular schwannoma, who received consent
排除标准
- •In addition to the vestibular schwannoma, if the brain has other underlying or systemic disease
- •During the observation period, other treatments were performed other than gamma knife surgery
- •If patients have a contraindication to MRI (eg, pacemaker, cochlear implants, hemodynamically unstable)
- •Concomitant use of gadolinium MRI contrast agents (eg, renal insufficiency [glomerular filtration rate <30 ML / min]), or if there was a side effect when using a contrast medium.
- •Adults with impaired ability to cope
- •If the images and medical records required for this study are not available or are not appropriate
结局指标
主要结局
Tumor size change before and after surgery
时间窗: pre-op, Immediately after surgery
次要结局
- In patients who underwent gamma knife surgery, the magnitude of tumor size change before and after surgery(through study completion, an average of 1 year)
研究者
Seung Hong Choi
SeoulNUH
Seoul National University Hospital
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