Type 2 Diabetes and the Effect of Probiotics
- Conditions
- EndotoxemiaHealthyType 2 Diabetes
- Registration Number
- NCT00413348
- Lead Sponsor
- Rigshospitalet, Denmark
- Brief Summary
Insulin-resistance in type 2 diabetes is associated with chronic inflammation. Anti-inflammatory actions might increase sensitivity to insulin. Since some probiotics have anti-inflammatory properties, ingestion of the probiotic bacteria Lactobacillus Acidophilus NCFM might increase insulin-sensitivity.
The inflammatory response to endotoxin injection and the insulin-sensitivity is examined before and after four weeks ingestion of probiotics.
- Detailed Description
Numerous studies have shown an association between insulin-resistance in type 2 diabetes and chronic low-grade inflammation. Some probiotics have an anti-inflammatory properties. Ingestion of probiotics might therefore, due to this property, increase sensitivity to insulin.
In this study type 2 diabetics (N=24) and healthy control (N=24) are given the probiotic bacteria Lactobacillus Acidophilus NCFM for four weeks. The anti-inflammatory effect is examined by evaluating the inflammatory response (White blood cell count, plasma-cytokines) to an iv injection of endotoxin (0,3 ng/kg) before and after the intervention. Also the insulin-sensitivity is measured with an hyperinsulinemic euglycemic clamp before and after L. acidophilus NCFM.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 48
- Healthy
- Type 2 diabetes
- Heart failure
- Lung disease
- Infections in the last two weeks before endotoxin injections.
- Treatment with antibiotics
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in insulin-resistance Change in inflammatory response to E. coli endotoxin injection
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Center of Inflammation and metabolism 7641 and Intensive Care Unit 4131, Rigshospitalet
🇩🇰Copenhagen, Denmark