NCT05014607Available不适用
Personalized Multi-peptide Vaccination in Combination With the TLR1/2 Ligand XS15 in Cancer Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- Available
研究概览
简要总结
The aim of this project is to provide personalized multi-peptide vaccination in combination with the TLR1/2 ligand XS15 to individual patients with advanced solid and hematological malignancies without any approved treatment options.
详细描述
Ethics: Patient treatment will be conducted according to §13 Absatz 2b, AMG.
研究设计
- 研究类型
- Expanded Access
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Documented diagnosis of advanced malignant disease
- •Advanced malignant disease without any available standard of care treatment option
- •Low tumor cell burden
- •Live expectancy > 6 month
- •Ability to understand and voluntarily sign an informed consent form.
- •Ability to adhere to the study visit schedule and other protocol requirements
- •Eastern Cooperative Oncology Group (ECOG) performance status score of ≤ 2.
排除标准
- •Pregnant or lactating females.
- •Treatment regimens inducing sever T cell deficiencies
- •Treatment-related side effect > CTC grade 2 (CTCAE V5.0
- •Participation in any clinical study or having taken any investigational therapy, which would interfere with the studys primary and secondary end points within 2 weeks prior to vaccination
- •Pre-existing auto-immune disease except for Hashimoto thyroiditis and mild (not requiring immunosuppressive treatment) psoriasis
研究者
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