Improvement in Muscle Mass with Nutrition in Patients with Liver Cirrhosis

Not yet recruiting

• Conditions: Alcoholic cirrhosis of liver, (2) ICD-10 Condition: K74||Fibrosis and cirrhosis of liver,

• Registration Number: CTRI/2023/12/060881
• Lead Sponsor: Sawai Man Singh Medical College

Brief Summary

Sarcopenia is definedas muscle wasting (progressive and generalized loss of muscle mass) togetherwith a decline of muscle function (loss of strength or physical performance).Sarcopenia has been associated with poorer survival in patients with cirrhosis. Nutrition may very well have direct influence on sarcopenia and functional status.There is no study on nutritional management of patients with sarcopenia. We will perform a randomized controlled study to assess the effects of nutritional therapy on sarcopenia in patients of cirrhosis.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-12-26
• Study Start: 2024-01-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 194

Inclusion Criteria

All patients with Liver Cirrhosis Sarcopenia.

Exclusion Criteria

• Patients with hepatic encephalopathy (grade≥ II according to the WestHaven Grading System).
• Uncontrolled esophageal varices bleeding.
• Refractory ascites.
• Malignancy.
• Patients with HPS or Portopulmonary Syndrome Severe renal dysfunction (estimated glomerular filtration rate< 30 ml/min/1.73 m2).
• Severe cardiac disease, history of gastrectomy.
• Patients with Neurological Disorders Previous poor compliance with pharmacologic treatment or nutritional counseling before initiating the trial supplement.
• Patients with a history of hepatocellular carcinoma.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the Change in Muscle Mass	0,1,3 & 6 months

Secondary Outcome Measures

Name	Time	Method
Improvement in albumin level, anthropometry parameters (mid arm circumference, triceps skin fold thickness, hand grip)	Improvement in CTP & MELD score.

Trial Locations

Locations (1)

Sawai Man Singh Medical College; 🇮🇳 Jaipur, RAJASTHAN, India

Sawai Man Singh Medical College

🇮🇳Jaipur, RAJASTHAN, India

DR SUDHIR MAHARSHI

Principal investigator

8130369247

sudhir.maharshi@gmail.com