Colloid vs Crystalloid Infusion Postoperative in CABG Patients Regarding Renal Hemodynamics and Function
Overview
- Phase
- Not Applicable
- Intervention
- crystalloid
- Conditions
- Renal Impairment
- Sponsor
- Sahlgrenska University Hospital, Sweden
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Change from baseline and differences inbetween groups in glomerular filtration rate, measured at different timepoints
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Comparing the effects of crystalloid versus colloid fluid resuscitation in CABG patients postoperatively regarding renal blood flow, glomerular filtration rate and renal oxygen demand.
Detailed Description
Due to blood loss and SIRS postoperative hypovolemia is a usual feature after CABG surgery. Substantial controversy persists regarding the best choice of fluid to be used for resuscitation in this setting regarding renal function and oxygen supply-demand matching. In our study we aim to investigate differences in functional renal parameters by dividing patients postoperatively in two groups, substituted either with crystalloid fluid, Ringer-Acetat, 20 ml/kg or colloid, HES 6% (130/0,4) 10 ml/kg under 20 minutes. Central and renal hemodynamics will be measured before (baseline) and after fluid administration by blood sampling and thermodilution in both pulmonary artery catheter and renal vein catheter. Measurement endpoints will mainly consist of central hemodynamics, renal blood flow, GFR and renal oxygen extraction rate which we aim to compare between groups.
Investigators
Jenny Skytte Larsson
MD
Sahlgrenska University Hospital, Sweden
Eligibility Criteria
Inclusion Criteria
- •elective fast track CABG patients, postoperative
Exclusion Criteria
- •hemodynamic instability
- •preoperative renal impairment
- •major postoperative bleeding
Arms & Interventions
crystalloid
crystalloid fluid administration, Ringer-acetat 20ml/kg under 30 minutes
Intervention: crystalloid
colloid
colloidal fluids administration, HES 6% (130/0,4) 7ml/kg under 30 minutes
Intervention: colloid
Outcomes
Primary Outcomes
Change from baseline and differences inbetween groups in glomerular filtration rate, measured at different timepoints
Time Frame: 125min after baseline-measures
GFR measured by thermodilution and blood- and urine sampling baseline1 (0min), baseline2 (+30min), timepoint1 (+65min), tp2 (+85min), tp3 (+105min), tp4 (+125min)