Traditional (24 hours) versus Abbreviated (6 hours) post partum magnesium sulphate therapy in patients with pre eclampsia with severe features: A Randomized Controlled Trial

This study is a randomized, double blind, parallel group, active control trial comparing the benefits of MgSO4 infusion for traditional 24 hours postpartum versus abbreviated 6 hours postpartum in patients with pre eclampsia with severe features. The primary objective of the study is To assess MgSO4 infusion for 24 hours postpartum is as effective as 6 hours postpartum in patients with preeclampsia with severe features. The secondary objectives being to assess total time of magnesium sulphate infusion prior to birth, occurrence of seizures postpartum number of seizures in post partum period and  time and duration of postpartum convulsion, postpartum bleeding, respiratory distress, time to onset of ambulation post partum and breastfeeding start time, use of postpartum antihypertensives, maternal death. Study population will be All Pregnant women diagnosed with pre-eclampsia with severe features at more than 20 weeks gestation willing to participate in study will be included in study. Patients refusing to give consent , patient with prior history of eclampsia before delivery, diagnosed with HELLP syndrome, known case of epilepsy, pre eclampsia with additional pathology such as renal failure, acute pulmonary edema, decompensated diabetes mellitus, autoimmune diseases, or hypertensive encephalopathy are excluded from the study. The expected outcome would be Abbreviated (6 hours) post partum magnesium sulphate therapy in patients with pre eclampsia with severe features is as effective as Traditional (24 hours) post partum magnesium sulphate therapy. Study population will be evaluated for 24 hours postpartum and total duration of study will be 2 years.