Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 93
- 试验地点
- 1
- 主要终点
- Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia
研究概览
简要总结
Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients.
Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied.
The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia.
详细描述
Growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center.
Patients who were lost from follow up or insufficient data about growth in the past will not included in the study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 5 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients in follow up with available medical charts.
排除标准
- •Patients lost from follow up or without enough data to calculate growth velocity or clinical and laboratory endocrine assessment or missing data about iron status.
结局指标
主要结局
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia
时间窗: One year
Analysis of Growth Velocity in Thalassemia and Sickle Cell Anemia and correlation with Iron Overload
次要结局
未报告次要终点
研究者
Dr Koren Ariel
Head of Pediatric Hematology Unit and Pediatric Dpt B
HaEmek Medical Center, Israel