Cognitive Enhancement Through Computerized Training
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Working Memory
研究概览
简要总结
Alcohol use disorder is characterized by widespread neurocognitive impairments, however despite substantial advances in the intervention and treatment of alcohol use disorders, exceptionally few studies have been directed to improving these deficits. This project leverages computerized cognitive training, applied as an adjunct to inpatient treatment, to enhance neurocognitive recovery. This project informs public health and future intervention efforts by interrogating factors critical to intervention efficacy and clarifying relationships between neurocognitive recovery and treatment outcomes, including post-discharge alcohol consumption.
详细描述
Programmatic investigation of neurocognitive functioning in alcohol use disorder (AUD) has revealed widespread and sustained impairments. Despite conceptual relevance to treatment efficacy, few AUD interventions have been directed to the remediation of these impairments. This project is responsive to this gap. It will answer critical questions regarding the potential of cognitive training (CT), applied as an adjunct to inpatient treatment, to improve cognitive recovery and post-discharge functional outcomes in AUD.
The current project will investigate the efficacy of two experimental cognitive training interventions in a sample of inpatients in treatment for AUD. While the effectiveness of CT to enhance function is supported by diverse literatures, it remains largely unexamined in AUD. The current project will interrogate the degree to which cognitive training interventions can "transfer" cognitive gains to untrained tasks/domains, and improve overall executive functioning. It will apply conceptual models from the CT and alcohol literatures to identify factors associated with CT efficacy. The impact of cognitive training on functional outcomes, including post-discharge drinking, will be investigated. Finally, relationships between cognitive recovery during treatment and post-discharge adaptation will be examined. Thus, the current work will be of substantial import to public health, alcohol science, and will inform future intervention efforts.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Minimum of 10 years of education
- •Meet DSM-5 criteria for alcohol use disorder
排除标准
- •Medical histories confounding interpretation regarding change in neuropsychological functioning (e.g., stroke)
- •Meet DSM-5 criteria for current/unremitted psychotic, panic, or bipolar disorders
研究组 & 干预措施
Inhibitory Control Training (IC)
Participants complete training in an inhibitory control task designed to utilize individually-adapted difficulty levels.
干预措施: Inhibitory Control Training (Behavioral)
Bias Modification Training (BM)
Participants complete training in an active comparator task designed to weaken approach responses to alcohol-associated cues.
干预措施: Bias Modification Training (Behavioral)
Working Memory Training (WM)
Participants complete training in a working memory task designed to utilize individually-adapted difficulty levels.
干预措施: Working Memory Training (Behavioral)
Non-Trained control (NTC)
No active intervention is delivered beyond typical care.
结局指标
主要结局
Working Memory
时间窗: Baseline and up to 3 weeks
Performance on neuropsychological measures indexing working memory capacity. Score range: 0-100 (scores \<40 are poor \[0-16th percentile\]; scores \>60 are good \[84th-100th percentile\]).
Inhibitory Control
时间窗: Baseline and up to 3 weeks
Performance on neuropsychological measures indexing inhibitory control capacity. Score range: 0-100 (scores \<40 are poor \[0-16th percentile\]; scores \>60 are good \[84th-100th percentile\]).
General Executive Function
时间窗: Baseline and up to 3 weeks
Performance on neuropsychological measures indexing general executive functioning. Score range: 0-100 (scores \<40 are poor \[0-16th percentile\]; scores \>60 are good \[84th-100th percentile\]).
Change in Working Memory Performance
时间窗: Baseline to Post-Test, Up to 3 months
Percent accuracy on neuropsychological measures indexing working memory capacity. Scores range from 0% to 100%, with higher percentages indicating better performance.
Change in Inhibitory Control Performance
时间窗: Baseline to Post-Test, Up to 3 months
Response time, in seconds, on neuropsychological measures indexing inhibitory control capacity. Values represent the change in response time from baseline to follow-up.
Change in General Executive Function Performance
时间窗: Baseline to Post-Test, Up to 3 months
Response time, in seconds, on neuropsychological measures indexing general executive functioning. Values represent the change in response time from baseline to follow-up.
次要结局
未报告次要终点