Exploratory clinical study on DNA methylation difference of whole gene in coronary heart disease patients with heat-toxin and blood-stasis syndrome and cold-coagulation and blood-stasis syndrome

Phase 1

• Conditions: Coronary atherosclerotic heart disease

• Registration Number: ITMCTR2200005725
• Lead Sponsor: Xiyuan Hospital,China Academy of Chinese Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

? Age from 30 to 75, no gender limitation;
? Patients with stable angina or unstable angina with coronary angiography and/or coronary CT confirmed at least one coronary artery stenosis =50% or with a clear history of myocardial infarction. Coronary angiography results were confirmed by 2 physicians with professional titles above deputy director;
? Patients with heat-toxin and blood-stasis syndrome and cold-coagulation and blood-stasis syndrome in TCM syndrome type diagnostic criteria.
? Sign informed consent.

Exclusion Criteria

Those who possess any of the following are excluded:
? Congenital heart disease, cardiomyopathy, coronary spasm, severe cardiopulmonary insufficiency (heart function above grade III, severe lung insufficiency);
? patients with acute cerebrovascular disease;
? Patients with hypertension and poor blood pressure control (systolic blood pressure = 180mmHg, diastolic blood pressure = 110mmHg);
? Complicated with chronic inflammatory diseases, severe infection, diabetes and poor blood glucose control, malignant arrhythmia, malignant tumor and multiple organ failure;
(5) with serious primary diseases such as liver, kidney and hematopoietic system, mental disorders can not express their will correctly and communication disorders;
? Patients who are participating in clinical trials of other drugs;
? Pregnant or lactating women;
? Alcoholism and drug abuse and addiction.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Routine urine test;RNA transcriptome;Electrocardiogram (ecg);Liver and kidney function tests;Haematology;DNA methylation;Coagulation function test;