A Phase I/II Single Arm Prospective Single Fraction Real-time Stereotactic Body Radiation Therapy Dose Escalation Trial of Rapid Helical TomoTherapy-based Radiation Therapy for Patients With Painful Osseous Metastatic Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 47
- 试验地点
- 2
- 主要终点
- Radiation Dose
研究概览
简要总结
The purpose of this research study is to evaluate the safety and effectiveness of an experimental procedure called Focused Radiation that may result in a faster way to plan and deliver radiation for the treatment of pain caused by metastatic bone tumors (cancerous tumors that originally came from another organ and have spread to bones). In this trial a single fraction of radiation will be given from 8-15 Gray.
详细描述
The purpose of this research study is to evaluate the safety and effectiveness of an experimental procedure called Focused Radiation that may result in a faster way to plan and deliver radiation for the treatment of pain caused by metastatic bone tumors (cancerous tumors that originally came from another organ and have spread to bones).
Focused radiation (the radiation is focused on the tumor in the bone with reduced radiation dose to the normal tissues) is used as standard of care treatment for patients with painful metastatic tumors in their spines with just one treatment. In this study, the focused radiation will be used to treat tumors in other bones as well. The current standard of care radiation treatment planning and delivery can take 2 to 3 weeks from start to finish depending on how many treatments are given although the standard of care is to treat patients with 1-10 treatments. The University of Virginia has developed an experimental workflow/process: a radiation treatment planning and delivery workflow called "STAT RAD" (STAT means "right away", and RAD means radiation). This experimental workflow will shorten the time it takes to plan and treat painful bone metastases to 1-2 hours.
When only one treatment is given the standard radiation dose is 8 Gray. This has resulted in radiation retreatment rates to the treated bone of 20% in prior studies for persistent or recurrent bone pain. In this study patients will be treated with higher doses of targeted radiation to determine if higher doses, which have been reported to be safely delivered for bone metastases in the spine with very low re-treatment rates, can be safely delivered to non-spine bone metastases. After the treatment, patients will be followed for pain relief in the treated bone, need for pain medication, quality of life, toxicity, and the need to retreat the bone metastasis for persistent or recurrent pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient has 1-3 major painful osseous metastases (target lesions)
- •Radiographic evidence (CT, MR, or PET CT) consistent with osseous metastatic disease on CT, MR, or PET CT obtained within 4 weeks of treatment will be used for pre-study treatment delivery. The GTV of the target lesions will be determined from this radiographic study and must be ≤ 250 cubic centimeters.
- •NOTE: Patient is still eligible if a diagnostic image set is not available within 4 weeks of treatment if the patient will undergo a kVCT simulation in the Department of Radiation Oncology with contouring directly onto this image set.
- •Patient is medically able to undergo palliative radiation therapy
- •Patient has pain that is persistent and distinguishably associated with the target sites to be treated
- •Planning Target Volume 1 (PTV1) must be > 5mm from the spinal cord or brain
- •Women of Childbearing age and men must consent to use adequate contraception for six months following study entry
排除标准
- •Inability to lie on the treatment table for 1 hour
- •Systemic therapeutic radionuclide delivery within 30 days prior to treatment
- •Target lesions have been previously treated with external beam radiation
- •Long bone target lesions with a Mirels fracture score >7
- •Unstable bone in the target lesion requiring surgical stabilization
- •PTV1 is located within 5mm of spinal cord or brain
- •A serious, uncontrolled medical disorder
- •Pregnancy
研究组 & 干预措施
Radiation Therapy
Stereotactic Body Radiation Therapy
干预措施: Stereotactic Body Radiation Therapy (Radiation)
结局指标
主要结局
Radiation Dose
时间窗: Up to 12 months following treatment
Determine the optimal dose range for treatment of osseous bone metastases with single SBRT (Stereotactic Body Radiation Therapy) treatment using the STAT RAD (right away/radiation) workflow
次要结局
- Paired Dose Pain Score Comparison(Up to 4 weeks following treatment)
- Post Treatment Measures(Up to 12 months following treatment)
- Single Treatment Pain Scores(Up to 4 weeks following treatment)
研究者
Paul W. Read, MD
Professor
University of Virginia