Impact of Anti-HLA Donor-specific Antibodies in ABO-incompatible Kidney Transplantation
- Conditions
- Kidney Transplant
- Registration Number
- NCT03423901
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
It was previously suggested an improvement of graft survival in ABO/HLA incompatible kidney transplantation (KT) compared with HLA (human leukocyte antigen) incompatible transplantation. Here, the investigators would analyse clinical, biological and histological results of ABO/HLA incompatible kidney transplant recipients, comparing with ABO or HLA compatible kidney transplantation.
- Detailed Description
The investigators propose to analyze the clinical, biological and histological course of kidney function, but also to investigate the T and B cells population after KT in ABO incompatible, ABO/HLA incompatible and HLA incompatible kidney transplantation (1 and 7 years posttransplantation in each groups).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 58
- Patient receiving a KT and followed at least one year in Toulouse Hospital
- Patient who have signed informed consent
- > 18 years old
- Patient under protective measures
- Patients treated for cancer, infectious or immune disease by molecules that could interfere with lymphocyte populations : Interleukin 6 (IL6) blockers, Programmed cell death 1(PD1) and the cytotoxic T-lymphocyte-associated antigen 4 (CTL4) blockers.
- Immunosuppressive treatments withdrawal - Patient in chronic dialysis
- Ongoing pregnancy or pregnancy in the past year
- Past of splenectomy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Gene expression related to antibody mediated rejection 1 year posttransplantation To determine expression of genes related to antibody mediated rejection (inflammation, and endothelial cell activation) by transcriptomic analyse (whole genome micro-array) on kidney biopsies
- Secondary Outcome Measures
Name Time Method description of T subsets cells 1 to 5 years posttransplantation to analyse of T subsets cells after Kidney transplantation in blood samples of patients by flow cytometry
description of B subsets cells 1 to 5 years posttransplantation to analyse of B subsets cells after Kidney transplantation in blood samples of patients by flow cytometry
Evolution of systematic annual kidney biopsies 1 to 5 years posttransplantation To analyse the evolution of systematic annual kidney biopsies by microscopy
Evolution of creatinine clearance 1 to 5 years posttransplantation to analyse creatinine clearance in blood samples of patients after kidney transplantation
description of lymphocytes rates 1 to 5 years posttransplantation to analyse rates of lymphocytes after Kidney transplantation in blood samples of patients by flow cytometry
Trial Locations
- Locations (1)
University Hospital
🇫🇷Toulouse, France
University Hospital🇫🇷Toulouse, France