Impact of Anti-HLA Donor-specific Antibodies in ABO-incompatible Kidney Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- Gene expression related to antibody mediated rejection
研究概览
简要总结
It was previously suggested an improvement of graft survival in ABO/HLA incompatible kidney transplantation (KT) compared with HLA (human leukocyte antigen) incompatible transplantation. Here, the investigators would analyse clinical, biological and histological results of ABO/HLA incompatible kidney transplant recipients, comparing with ABO or HLA compatible kidney transplantation.
详细描述
The investigators propose to analyze the clinical, biological and histological course of kidney function, but also to investigate the T and B cells population after KT in ABO incompatible, ABO/HLA incompatible and HLA incompatible kidney transplantation (1 and 7 years posttransplantation in each groups).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient receiving a KT and followed at least one year in Toulouse Hospital
- •Patient who have signed informed consent
- •> 18 years old
排除标准
- •Patient under protective measures
- •Patients treated for cancer, infectious or immune disease by molecules that could interfere with lymphocyte populations : Interleukin 6 (IL6) blockers, Programmed cell death 1(PD1) and the cytotoxic T-lymphocyte-associated antigen 4 (CTL4) blockers.
- •Immunosuppressive treatments withdrawal - Patient in chronic dialysis
- •Ongoing pregnancy or pregnancy in the past year
- •Past of splenectomy
结局指标
主要结局
Gene expression related to antibody mediated rejection
时间窗: 1 year posttransplantation
To determine expression of genes related to antibody mediated rejection (inflammation, and endothelial cell activation) by transcriptomic analyse (whole genome micro-array) on kidney biopsies
次要结局
- description of T subsets cells(1 to 5 years posttransplantation)
- description of B subsets cells(1 to 5 years posttransplantation)
- Evolution of systematic annual kidney biopsies(1 to 5 years posttransplantation)
- Evolution of creatinine clearance(1 to 5 years posttransplantation)
- description of lymphocytes rates(1 to 5 years posttransplantation)