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临床试验/NCT06922396
NCT06922396招募中不适用

Predictors of Mortality Among Patients With Head Trauma

Ayman Mahmoud Alsayes1 个研究点 分布在 1 个国家目标入组 140 人开始时间: 2024年6月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
140
试验地点
1
主要终点
The studied patients will be observed for 1 month and mortality will be recorded.

研究概览

简要总结

Evaluate the usefulness of the APACHE II (Acute Physiology and Chronic Health Evaluation II), RTS (Revised trauma score), GCS (Glasgow Coma Scale) scores and various variables as age, sex, lab.data and complications in predicting mortality of patients with traumatic brain injury (TBI) in the intensive care unit (ICU).

详细描述

Head injuries are a major cause of morbidity and mortality through out the world. It is estimated that 69 million people suffer from Traumatic Brain Injury (TBI) from all cases per year .

Current estimates suggest that about 4.48 million people lose their lives due to injuries which accounts for 8% of all deaths globally. Of these, an estimated 2 million deaths were attributed to the TBI, and the burden was concentrated in developing countries due to limited access to advanced life-sustaining measures after trauma .

In low-and middle-income countries, head injury patients have worse outcomes than patients in high-income countries . Several studies in Africa have found that death rates from head injury range from 4.2% to 35% .

Evidence suggests that the possible causes for the high mortality rate could be older age, male gender,low GCS, and cause of injuries are likely non-modifiable risk factors and hypoxia, hypotension, hyperthermia, hypo or hyperglycemia, and did not undergo surgery or poor adherence to management guidelines are possible modifiable risk factors .

Clinical presentation of patients and advanced rescue care by emergency teams are crucial factors to determining favorable outcomes. Accordingly, non-surgical management should emphases on rapid transportation, avoiding hypotension and hypoxia, hyperthermia, and medical management to reduce brain edema .

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
16 Years 至 75 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •All patients with acute traumatic brain injury older than 16 years where presented in emergency department within 24 hours of trauma with a Glasgow coma scale less than 15

排除标准

  • •o Post cardiac arrest
  • •Patients with GCS=
  • •Patients with associated advanced cervical spine, maxillofacial, severe chest trauma.
  • •Patients with previous neurological disorders

结局指标

主要结局

The studied patients will be observed for 1 month and mortality will be recorded.

时间窗: average 6 to 9 months

次要结局

未报告次要终点

研究者

发起方
Ayman Mahmoud Alsayes
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Ayman Mahmoud Alsayes

Predictors of Mortality among Patients with Head Trauma

Ain Shams University

研究点 (1)

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