Kidney Function Markers in Postmenopausal Obese Women: Response to Aerobic Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- eosinophils
研究概览
简要总结
The goal of this clinical trial is to investigate the impact of a 10-week moderate intensity interval walking training (MIIWT) program on kidney function markers in obese postmenopausal women. The main question it aims to answer is:
Does MIIWT improve kidney function markers in this population? Researchers will compare MIIWT (designed to training group) to non-training intervention (designed to control group) to see if the training program works to improve kidney function markers.
Participants in training group will: perform a 10-week MIIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.
详细描述
The convergence of the obesity pandemic and the postmenopausal status is likely associated with renal function decline. Regular aerobic training have been shown to prevent adverse health outcomes in obese. The main purpose of this study was to evaluate changes in kidney function markers and white blood cell (WBC) subpopulations in obese postmenopausal women participating in moderate intensity interval walking training (MIIWT). A total of 36 obese postmenopausal women were randomized to MIIWT (CON, n=18) or control group (CON, n=18), four times a week for 10-week. The MIIWT consisted on 5 repetitions of walking for 6-min at 60-80% of the 6-min-walk-test-distance with 6-min of active recovery between repetitions. Before and after the MIIWT, body composition, kidney function markers (serum creatinine [sCr], blood urea nitrogen [BUN], serum uric acid [sUA] and Glomerular Filtration Rate [GFR] and white blood cells (WBC) count and its specific subpopulations (neutrophils [NEU], lymphocytes [LYM], monocytes [MON], eosinophils [EOSI] and basophils [BASO]) were assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •be aged between 50 and 60 years.
- •be postmenopausal (absence of menses > 12 months).
- •present a BMI greater than or equal to 30 kg/m
- •be free of any special diets in the three months prior to the start of the intervention.
- •have a sedentary lifestyle (exercise less than 2 h/week).
排除标准
- •Suffering from any cardiovascular/renal/pulmonary/metabolic disease.
- •Being under menopausal hormone therapy.
- •Presenting any orthopedic limitations interfering the ability to perform the study intervention.
研究组 & 干预措施
Training group
The training group underwent a moderate intensity intermittent walking training at 60% to 80% of the 6- min-walking-test distance, four times a week of 60 min/session for a period of 10 weeks.
干预措施: walking intervention (Behavioral)
Control group
No training intervention was intended for the control group.
结局指标
主要结局
eosinophils
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
blood concentrations of eosinophils (EOSI) ) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
basophils
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
blood concentration of basophils (BASO) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
serum creatinine
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
serum concentrations of creatinine (sCr) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
blood urea nitrogen
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
serum concentrations of blood urea nitrogen (BUN) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
serum uric acid
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
serum concentrations of uric acid (sUA) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
glomerular Filtration Rate
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
the glomerular Filtration Rate (GFR) has been computed using the Cockcroft formula, as follows: GFR (mL/min) = \[(140 - age) × weight ×0.85\]/(sCr× 72).
white blood cells count
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
blood concentration of white blood cells (WBC) count were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany)
neutrophils
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
blood concentration of neutrophils (NEU) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
lymphocytes
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
blood concentrations of lymphocytes (LYM) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
monocytes
时间窗: At baseline and at week 11(after the ten weeks of the training intervention).
blood concentration of monocytes (MON) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
次要结局
- Body composition(At baseline and after ten weeks of the training intervention.)
- 6 min walking test(At baseline and after ten weeks of the training intervention.)
研究者
Wissal Abassi
Principal Investigator
High Institute of Sports and Physical Education of Kef