Hyperglycemia, Exercise, and Endothelial Function

Not Applicable

Completed

• Conditions: Hyperglycemia; Endothelial Function
• Interventions: Behavioral: GLU+EX; Dietary Supplement: GLU

• Registration Number: NCT03651713
• Lead Sponsor: University of Iowa

Brief Summary

The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Detailed Description

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Study Timeline

• Study First Submitted: 2018-08-22
• Study First Submitted QC: 2018-08-27
• Study First Posted: 2018-08-29
• Study Start: 2018-10-15
• Primary Completion: 2019-10-21
• Study Completion: 2019-10-21
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-23
• Last Update Posted: 2020-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

• Healthy young men 18-35 years of age.

Exclusion Criteria

• Hypertension,
• Hyperlipidemia,
• Smoking,
• Heart disease,
• Chest pain upon exertion,
• Previous heart surgeries or history of arrhythmias,
• Diabetes,
• Obesity (body mass index ≥30kg/m2),
• Kidney disease,
• Pulmonary disease,
• Autonomic disorders,
• Individuals whom engage in structured exercise (≥30min, ≥2d/wk),
• Current use of medications which influence outcome measures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
GLU+EX	GLU+EX	Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol.
GLU	GLU	Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise.

Primary Outcome Measures

Name	Time	Method
Change in Vascular Endothelial Function	Before and after the seven-day intervention in both groups.	Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention.

Secondary Outcome Measures

Name	Time	Method
Central Blood Pressure	Before and after the seven-day intervention in both groups.	Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions.

Trial Locations

Locations (1)

Medical Education Building; 🇺🇸 Iowa City, Iowa, United States