Immunopathologic Profiles of the Lung Micro- Environment Using Cryobiopsies and Identification of Blood Biomarkers in Patients With IPF
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Idiopathic Pulmonary Fibrosis
- Sponsor
- University of Aarhus
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- PD-L1
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in patients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in patients with IPF compared with other interstitial lung diseases.
Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.
Detailed Description
Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in cryobiopsies from the lungs inpatients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in blood samples in patients with IPF compared with other interstitial lung diseases. Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients suspected of having an ILD who are having cryobiopsies performed
Exclusion Criteria
- •BMI \> 35
- •DLCO \< 35%
- •FVC \< 45%
- •Pulmonary hypertension
- •Cardiac or other severe comorbidity that will increase the risk of complications
Outcomes
Primary Outcomes
PD-L1
Time Frame: At diagnosis
Expression of PD-L1 in the epithelial cells in lungs