Immunopathologic Profiles and Blood Biomarkers in Patients With IPF
- Conditions
- Idiopathic Pulmonary Fibrosis
- Registration Number
- NCT04187079
- Lead Sponsor
- University of Aarhus
- Brief Summary
Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in patients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in patients with IPF compared with other interstitial lung diseases.
Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.
- Detailed Description
Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in cryobiopsies from the lungs inpatients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in blood samples in patients with IPF compared with other interstitial lung diseases.
Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Patients suspected of having an ILD who are having cryobiopsies performed
- BMI > 35
- DLCO < 35%
- FVC < 45%
- Pulmonary hypertension
- Cardiac or other severe comorbidity that will increase the risk of complications
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PD-L1 At diagnosis Expression of PD-L1 in the epithelial cells in lungs
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Aarhus University Hospital, Department of Respiratory Diseases and Allergy
🇩🇰Aarhus, Denmark