Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa
概览
- 阶段
- 不适用
- 干预措施
- AN-R
- 疾病 / 适应症
- Anorexia Nervosa
- 发起方
- University of California, San Diego
- 入组人数
- 252
- 试验地点
- 2
- 主要终点
- BOLD response
- 状态
- 招募中
- 最后更新
- 4天前
概览
简要总结
The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39.
Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC.
Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC.
Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later.
Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.
研究者
Christina Wierenga
Professor
University of California, San Diego
入排标准
入选标准
- •Eating Disorder Group:
- •Between the ages of 18 and 39 years old
- •Meet DSM-V criteria for AN-R, AN-BP, or BN
- •Healthy Control Group:
- •Between the ages of 18 and 39 years old
- •Have maintained 85% to 120% ideal body weight since menarche
排除标准
- •All Groups:
- •Psychotic illness/other mental illness requiring hospitalization
- •Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures.
- •Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
- •Neurological disorder, neurodevelopmental disorder, or history of head injury with \>30 min loss of consciousness
- •Any contraindication to undergoing an MRI
- •Primary obsessive compulsive disorder or primary major depressive disorder
- •Additional Exclusion Criteria for ED Group:
- •If taking other psychotropic medication, any change in dosage in the 2 weeks before scanning
- •Additional Exclusion Criteria for Healthy Control Group:
研究组 & 干预措施
AN-R
Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa restricting subtype.
AN-BP
Participants that meet DSM-V criteria for Anorexia Nervosa binging/purging subtype
BN
Participants that meet DSM-V criteria for Bulimia Nervosa.
Healthy Controls
Participants that do not meet DSM-V criteria for any disorder.
结局指标
主要结局
BOLD response
时间窗: 1 Year
Brain activity associated with 'liking', 'wanting', and learning
Reward and Punishment Learning
时间窗: 1 Year
Task reinforcement learning rate in reward and punishment trials
Connectome-based predictive modeling (CPM)
时间窗: 1 Year
Functional connectivity maps from task-based fMRI data and clinical data