Clinical Trials/NCT04505384

NCT04505384

Completed

N/A

Acute Effects of Left Bundle Branch Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy

Shanghai Zhongshan Hospital1 site in 1 country25 target enrollmentSeptember 1, 2020

ConditionsHeart Failure Cardiac Pacing, Artificial Cardiac Resynchronization Therapy

Overview

Phase: N/A
Intervention: Not specified
Conditions: Heart Failure
Sponsor: Shanghai Zhongshan Hospital
Enrollment: 25
Locations: 1
Primary Endpoint: Hemodynamic parameter LV dP/dt(max)
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The study was designed to compare the acute effects of left bundle branch pacing (LBBP) with biventricular pacing (BVP) in patients with left ventricular ejection fraction (LVEF) <=35% with left bundle branch block (LBBB).

Detailed Description

The metrics include electrocardiographic, echocardiographic and hemodynamic parameters to evaluate and compare LBBP with BVP for resynchronization therapy in patients with heart failure and LBBB.

Registry

clinicaltrials.gov

Start Date

September 1, 2020

End Date

December 31, 2021

Last Updated

4 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Shanghai Zhongshan Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•NYHA class II-IV;
•LVEF \<=35%;
•LBBB with QRS duration \>=130ms.

Exclusion Criteria

•moderate-to-severe aortic stenosis;
•frequent premature ventricular complexes;
•signiﬁcant peripheral vascular disease.

Outcomes

Primary Outcomes

Hemodynamic parameter LV dP/dt(max)

Time Frame: 1 hour

LV dP/dt(max) will be obtained during implant procedure.

Secondary Outcomes

Mechanical parameters including Ts-SD and IVMD(0.5 hour)
Electrical synchrony parameters including QRS duration and QRS area(0.5 hour)

Study Sites (1)

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