ate Adverse effects in Dutch testicular cancer survivors: a Nationwide case-control study on Cardiovascular Events (LANCE study)
Recruiting
- Conditions
- cardiovascular disease100110821003859710003216heart- and vessel disease
- Registration Number
- NL-OMON30146
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
For all participants:
- 18 years and older
- treatment for non-seminomatous testicular cancer between 1977 and 1996
- age of 50 years or younger at start of initial treatment
- at least 5 years after treatment;For cases:
- diagnosis of a major cardiac event (myocardial infarction or proven coronary artery disease) at least 5 years after treatment for testicular cancer
Exclusion Criteria
For all participants:
- treatment with mediastinal radiotherapy;For controls:
- no diagnosis of a major cardiac event (myocardial infarction or proven coronary artery disease) after treatment for testicular cancer
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameters consist of cardiovascular risk factors that are<br /><br>evaluated by physical examination and analysis of blood and urine. Examples are<br /><br>obesity, hypertension, hypercholesterolaemia and albuminuria. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters consist of genetic polymorphisms that are<br /><br>potentially involved in long-term cardiovascular toxicity following treatment<br /><br>for testicular cancer. In addition, quality of life following treatment for<br /><br>testicular cancer will be assessed by means of a questionnaire.</p><br>