Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- resting metabolism
研究概览
简要总结
The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and Females
- •Age: 25-45 years
- •Overweight or obese (BMI=25.0-34.9 kg/m²)
- •Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)
- •Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)
- •Not meeting weekly physical activity recommendations (<150 min moderate-intensity exercise, <75 minutes of vigorous-intensity exercise, and <2 days of strength training)
- •Not following a diet that is restrictive or eliminates certain food group/types
排除标准
- •Allergies to nuts, especially tree nuts
- •Has a pacemaker
- •Following a diet that is restrictive or eliminates certain food group/types
- •Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer/cancer treatment (within the past year)
- •History of gastrointestinal surgery, hysterectomy
- •For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal
研究组 & 干预措施
Pistachio
Four days of pistachio snacking, to be consumed mid-morning (1oz; 9-11am), mid-afternoon (1oz; 2-4pm), and pre-sleep (0.5 oz; within 1hr of bedtime), while otherwise maintaining normal dietary habits. An addition snack will be consumed post-exercise (0.5oz).
干预措施: Pistachio (Other)
Control
Maintain normal dietary habits for four days.
结局指标
主要结局
resting metabolism
时间窗: Day 0 and Day 5
resting metabolic rate (RMR) and substrate utilization (RER) via indirect calorimetry
exercise metabolic flexibility
时间窗: Day 0 and Day 5
substrate metabolism (RER; indirect calorimetry) throughout a submaximal, graded exercise test
post-exercise metabolism
时间窗: Day 0 and Day 5
Energy expenditure and substrate metabolism (RER) measured at 0, 30, 60, 90min post-exercise via indirect calorimetry
次要结局
- Caloric Intake(Day 0 and Day 4)
- Carbohydrate Intake(Day 0 and Day 4)
- Protein Intake(Day 0 and Day 4)
- Fat Intake(Day 0 and Day 4)
研究者
Katie Hirsch
Assistant Professor
University of South Carolina