Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers

University Hospital, Clermont-Ferrand1 个研究点分布在 1 个国家目标入组 53 人开始时间: 2020年8月27日最近更新: 2026年8月7日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 53
试验地点: 1
主要终点: changes of blood metabolomics

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The dietary shift from animal to plant protein sources is one of the key aspects of the nutritional transition towards more sustainable food system and diets. However the metabolic implication of this shift in protein sources are still poorly understood.

This project aims to characterize and understand the metabolic orientations specifically induced by animal and vegetable dietary proteins, in order to better analyze the metabolic reorientations that would result from the expected increase in the share of plant proteins in different dietary contexts, especially those of the Western type, often associated with the development of metabolic deregulations (obesity and cardiometabolic risk).

详细描述

The main objectives of this project are:

Characterize the metabolic adaptations induced by animal or plant protein diets and their repercussions in terms of physiology and health.
Characterize the medium-term metabolomic signatures induced by this shift in dietary protein sources
Validate, in a human population, biomarkers of dietary animal or plant proteins, previously identified in pre-clinical studies.

This clinical trial is open, monocentric, controlled, randomized, with a cross experimental design.

20 men or postmenopausal women will follow for 4 weeks a controlled diet with a protein fraction constituted mainly from animal or vegetal sources. After a 2-week washout period(+21D/-7D), they will follow another 4 week of controlled diet with predominantly animal or plant protein depending on 1st intervention period diet.

At the end of each intervention period, a post-prandial exploration will be conducted with the administration of a high-fat, high-sugar meal and subsequent blood and urine sampling.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Basic Science
盲法: None

入排标准

年龄范围: 25 Years 至 55 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•BMI between 25 and 35 kh/m² (terminals included)
•Waist circumference ≥ 94 cm for men and ≥80 cm for women
•at the choice, one of the following criteria: Triglyceridemia > 1.49g/L, fasting blood glucose≥ 5.6 mmol/L , a HDL cholesterol <1.03mmol/L for men or <1.29 mmol/L for women , systolic blood pressure≥ 130 mmHg or diastolic≥ 85 mmHg .

排除标准

•Systolic blood pressure > 150mmHg or diastolic blood pressure > 90mmHg
•pathology and medical treatment
•Smoking > 4 cigarettes /day
•Alcohol consumption > 2 glasses/day
•Antibiotics taken during the last 3 months before the clinical trial
•Specific diets

研究组 & 干预措施

Hypertriglyceridimic/blood sugar/HDLcholesterol/blood pressure waist phenotype/plant protein source

Experimental

20 men or postmenopausal women between 25 and 55 years old with a high waist circumference and at the choice, one of the following criteria high triglyceridemia, blood sugar above standards,a lower than standard HDL-cholesterol level,slightly elevated blood pressure receiving diets with predominantly plant protein sources

干预措施: Diets with predominantly plant protein sources (Behavioral)

Hypertriglyceridimic/blood sugar/HDLcholesterol/blood pressure waist phenotype/animal protein source

Experimental

干预措施: Diets with either predominantly animal protein sources. (Behavioral)