The clinical time-effect study of combined application of Xingnao Kaiqiao therapy and mechanical recanalization in the treatment of acute ischemic stroke patients with large vessel occlusion

Dongfang Hospital Beijing University of Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

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•1. Aged >=18 years old;
•2. Clinical diagnosis of acute ischemic stroke, the clinical symptoms or signs are considered to be caused by intracranial and extracranial large artery occlusion. Hospitals with conditions recommend non-invasive imaging examination to confirm the diagnosis of the responsible large vessel occlusion;
•3. Neurological deficit score (NIHSS) >=6 points; ASPECT score >=6 points;
•4. The time from the onset of the anterior circulation to the completion of femoral artery puncture is within 6 hours. If there is an obvious ischemic penumbra, the thrombus removal time window can be extended to 6~24 hours according to the patient's condition;
•5. It is reasonable to perform post-circulation mechanical thrombectomy therapy;
•6. CT or MR examination to rule out intracranial hemorrhage and large-scale cerebral infarction. A large area cerebral infarction in the anterior circulation is defined as CT or DW imaging, ASPECTST score <6 points, or infarct volume >=70ml, or infarct volume >1/3 of the middle cerebral artery blood supply area; a large area cerebral infarction in the posterior circulation is defined as infarct volume> 1/3 brainstem volume.

•1. Hemorrhagic constitution or receiving anticoagulation treatment, including coagulation factor deficiency disease, international normalized ratio (INR)>1.7;
•2. Active bleeding or major surgery in the past 2 weeks, significant trauma or bleeding disease;
•3. The modified Rankini scale score (mRs) of the patients before the stroke occurred>3;
•4. Seriously allergic to contrast agents;
•5. Refractory hypertension that cannot be controlled by drugs (continuous systolic blood pressure >=185mmg, or continuous diastolic blood pressure >=110mmHg);
•6. Blood sugar <2.8mmol/L or >22.0mimo/L;
•7. The platelet count is less than 100x19/L;
•8. Serious heart, liver and kidney function abnormalities;
•9. Pregnancy;
•10. Suspected infectious emboli, such as septic emboli or bacterial endocarditis;
•11. End-stage disease leads to life expectancy of patients <3 months.

发起方

Dongfang Hospital Beijing University of Chinese Medicine