Comparison The Emergence Time After Discontinuation Of Sevoflurane With Fresg Gas Flo w 4L/min and 0.8L/min During Emergence While in Maintanence Phase The Fresh Gas Flow is kept at 0.8L/min
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Primary objective: Comparing the emergence time after discontinuation of sevoflurane with fresh gas flow of 4l/min and 0.8l/min during emergence while in maintenance phase the fresh gas flow is kept at 0.8l/min
研究概览
简要总结
After obtaining institutional ethics committee’s approval and written informed consent patients undergoing surgeries under general anaesthesia will be recruited in this study. Participants will be allotted in to two groups through balanced randomization. A computer software viz. WINPEPI will be used for the randomization. The treatment allocation will be kept in a sealed opaque envelopes and they will be opened after written informed consent of eligible participants. Preoperative assessment will be done and written informed consent will be obtained from all the patients who fulfil the inclusion criteria. Patients will be randomly assigned to any one of the two groups.
Group H - FGF will be increased to 4L/min and sevoflurane will be discontinued at the last skin stitch at the end of surgery and time of discontinuation of sevoflurane , time of patient’s spontaneous movement , eye opening and time of extubation is noted .
Group S - FGF will be continued at 0.8L/min during emergence and sevoflurane will be discontinued 20 minutes prior to last skin stitch at the end of surgery and time of discontinuation till the patient’s spontaneous movement , eye opening and time of extubation will be noted .
Method of assessment:
Variables to be assessed after discontinuation of sevoflurane
· Time of eye opening(min)
· Time of spontaneous movement (min)
· Time of extubation (min)
· End tidal concentration of sevoflurane at various time –
1) At sevoflurane discontinuation
2) At eye opening
3) At spontaneous movement
4) At extubation
· Entropy at various time-
1) At sevoflurane discontinuation
2) At eye opening
3) At spontaneous movement
4) At extubation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 19.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient undergoing surgery under General Anaesthesia with surgery hour more than 1 hour and using cuffed Endotracheal Tube.
- •Patient with ASA status I, II and III.
- •Patient weight between 30 to 80 kgs.
排除标准
- •1.Patients refusing in taking part in the study 2.Neurological surgeries 3.Post operative patient who remain intubated or require elective ventilation 4.Patient of acute alcohol intoxication 5.Patient of diabetic keto acidosis.
结局指标
主要结局
Primary objective: Comparing the emergence time after discontinuation of sevoflurane with fresh gas flow of 4l/min and 0.8l/min during emergence while in maintenance phase the fresh gas flow is kept at 0.8l/min
时间窗: 0 minutes to 20 minutes
次要结局
- 1. To compare time of eye opening after discontinuation of sevoflurane in both the groups(2. To compare time of spontaneous movement after discontinuation of sevoflurane in both the groups)
研究者
Dr. Madhavi Chaudhari
PRAMUKH SWAMI MEDICAL COLLEGE,BHAIKAKA UNIVERSITY