Neuropathic Pain in Psoriatic Arthritis

Completed

• Conditions: Psoriatic Arthritis
• Interventions: Other: painDETECT questionnaire; Other: Douleur Neuropathique 4 questionnaire (DN4); Other: Short form-36; Other: Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC); Other: Numeric Rating Scale; Other: Disease activity in psoriatic arthritis (DAPSA)

• Registration Number: NCT05223049
• Lead Sponsor: Bezmialem Vakif University

Brief Summary

Pathogenesis of inflammatory diseases is suitable for eliciting neuropathic pain. The aim of this study is to evaluate the frequency of NP among PsA patients and relationship between disease activity, quality of life, functionality, and other numerous factors.

Detailed Description

Neuropathic pain (NP) is the pain arising from a primary lesion or a dysfunction of nervous system. NP can affect central or peripheral nervous system and can be caused by numerous factors such as inflammation or neuroplastic changes. Inflammation can sensitize nociceptors in sensory nerves by promoting prostaglandin E2 and I2 secretion thus, cause neuropathic pain. Besides, a mixed pain pattern with neuropathic components is thought to be developed in chronic pain conditions. In this point of view, pathogenesis of inflammatory diseases is suitable for eliciting NP. In arthritic joints, even non-arthritic tissues are affected by the disease and a condition called peripheral sensitization develops. Previous studies about NP and inflammatory diseases link have focused on rheumatoid arthritis and number of studies about NP and psoriatic arthritis (PsA) is limited. In this manner the aim of this study is to evaluate the frequency of NP among PsA patients and relationship between disease activity, quality of life, functionality, and other numerous factors.

Study Timeline

• Study Start: 2022-01-22
• Study First Submitted: 2022-01-23
• Study First Submitted QC: 2022-01-23
• Study First Posted: 2022-02-03
• Primary Completion: 2022-03-15
• Study Completion: 2022-03-15
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-04
• Last Update Posted: 2022-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• being aged≥18
• being diagnosed PSA according to CASPAR criteria

Exclusion Criteria

• additional conditions that could cause neuropathic pain (e.g. radiculopathy, polyneuropathy, depression, fibromyalgia)
• history of fracture or surgery
• endocrinopathies that could cause neuropathic pain (e.g. DM)
• malignancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Psoriatic Arthritis patients with neuropathic pain	Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC)	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≥4 or PainDETECT score of ≥13.
Psoriatic Arthritis patients with neuropathic pain	Disease activity in psoriatic arthritis (DAPSA)	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≥4 or PainDETECT score of ≥13.
Psoriatic Arthritis patients with neuropathic pain	painDETECT questionnaire	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≥4 or PainDETECT score of ≥13.
Psoriatic Arthritis patients with neuropathic pain	Short form-36	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≥4 or PainDETECT score of ≥13.
Psoriatic Arthritis patients with neuropathic pain	Numeric Rating Scale	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≥4 or PainDETECT score of ≥13.
Psoriatic Arthritis patients with nonneuropathic pain	Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC)	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≤4 or PainDETECT score of ≤13.
Psoriatic Arthritis patients with neuropathic pain	Douleur Neuropathique 4 questionnaire (DN4)	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≥4 or PainDETECT score of ≥13.
Psoriatic Arthritis patients with nonneuropathic pain	painDETECT questionnaire	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≤4 or PainDETECT score of ≤13.
Psoriatic Arthritis patients with nonneuropathic pain	Douleur Neuropathique 4 questionnaire (DN4)	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≤4 or PainDETECT score of ≤13.
Psoriatic Arthritis patients with nonneuropathic pain	Short form-36	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≤4 or PainDETECT score of ≤13.
Psoriatic Arthritis patients with nonneuropathic pain	Numeric Rating Scale	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≤4 or PainDETECT score of ≤13.
Psoriatic Arthritis patients with nonneuropathic pain	Disease activity in psoriatic arthritis (DAPSA)	Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≤4 or PainDETECT score of ≤13.

Primary Outcome Measures

Name	Time	Method
Short form-36 survey in two groups	1 day	The statistical difference between two groups in terms of SF-36 and subdomains
Frequency neuropathic pain in psoriatic arthritis patients	1 day	The frequency of neuropathic pain in the PSA patients included in the study according to painDETECT and DN4 scores.
Disease activity in Psoriatic arthritis (DAPSA) score in two groups	1 day	The statistical difference between two groups in terms of disease activity
Numeric Rating Scale (rest, movement) in two groups	1 day	The statistical difference between two groups in terms of disease activity
SPARCC enthesitis index in two groups	1 day	he statistical difference between two groups in terms of SPARCC

Trial Locations

Locations (1)

Bezmialem Vakif University; 🇹🇷 Istanbul, Fatih, Turkey